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15 hasil
7-day Atorvastatin and Emotional Processing
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Depression is common and associated with considerable health disability. Traditional antidepressants mainly work by modulating monoamine levels in the synaptic cleft; however, the evidence that depression is caused by impaired serotonin or noradrenaline activity is weak and inconsistent, and indeed
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea
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The dogma over the past 3 decades, particularly in the field of sleep medicine, has been that intermittent hypoxia (IH) is a detrimental stimulus that leads to a number of co‐morbidities including autonomic (e.g. increased sympathetic nervous system activity), cardiovascular (e.g. hypertension,
Glycemic Control and Endothelial Function in Patients With Type 2 Diabetes
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The study is performed on one group of patients with type 2 diabetes and one group of age-matched healthy controls
Inclusion criteria:
1. Type 2 diabetes
2. Poor glycaemic control defined as a mean day blood glucose >12 mmol/L.
Exclusion criteria:
1. Age >80 years.
2. HbA1c <70 mmol/mol
3.
Paroxetine-mediated GRK2 Inhibition to Reduce Cardiac Remodeling After Acute Myocardial Infarction
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Cardiac remodeling is characterized by a composite of structural, geometric, molecular, and functional changes of the myocardium, and is an important determinant of heart failure and cardiovascular outcome in survivors of acute myocardial infarction. Progression of heart failure secondary to the
Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud
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Raynaud's phenomenon (RP) is an exaggerated vascular response characterized by at least biphasic change (pallor and cyanosis) in the skin color of the digits, induced by cold temperature or emotional stress, The prevalence varies from 3 to 5%. In primary RP, there is no evidence of a secondary cause
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke
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Tryptophan (TRP), an essential aminoacid, is metabolized in the serotonin (5-HT) or in the kynurenine (KYN) pathway. Serotonin is catabolized to 5-HIAA (5-hydroxyindole amino acid) by monoamine oxidase A (MAOA). The TRP to KYN transformation is regulated by indoleamine 2,3-dioxygenase (IDO).
The
Daily Ginger Drinking and Platelet Function
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Herbal medicine products are dietary supplements that people take to improve their health. Many herbs have been used for a long time for claimed health benefits. They are sold as tablets, capsules, powders, beverages, extracts and fresh or dried plants. Herbal medicines have been associated with
Effect of Sarpogrelate, a Serotonin Receptor Antagonist, on Coronary Artery Disease
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Type 2 diabetes has been increased exponentially, arousing serious economic, social and health repercussions. Also, macrovascular complications of diabetes such as myocardial infarct or stroke have been increased. Individuals with diabetes have a greater risk of cardiovascular disease (CVD),
The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome
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AIM Depression after Acute coronary syndrome (ACS - myocardial infarction and unstable angina) is highly prevalent and associated with a 2.5 fold increased in all-cause morbidity and mortality. Sleep disturbances is an integrated part of the pathology of depression and have severe consequences for
Effects of Repetitive Transcranial Magnetic Stimulation in the Treatment of Phantom Limb Pain in Landmine Victims: ANTARES
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Background In 2007 Colombia was one of the five countries in the world with the highest number of anti-personnel landmine victims [1]. These are small devices designed to injure or kill people and animals by exploding when a minimum pressure is exerted on them (approximately 6 Force-Kg) [2]. Between
Type II Diabetes Mellitus in Patients Exposed to Pravastatin and Paroxetine
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A Double Blind Placebo Study to Determine the Effectiveness of Theramine on the Management of Chronic Back Pain
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The diagnosis and management of back pain is a challenge for both primary care physicians and specialists. Establishing an etiology can be difficult and often problematic, with treatment options capable of producing serious and potentially life threatening side effects. Treatments often exert a
Effect of Paroxetine on COAT-Platelet Production in Normal Volunteers and Patients With Cardiovascular Disease
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DECARD: Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome
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Postmenopausal Hormone Therapy in Unstable Angina
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BACKGROUND:
Unstable angina is a frequent diagnosis in post-menopausal women and is associated with a significant risk of myocardial infarction and need for revascularization. The pathogenesis of unstable angina involves vasoconstriction superimposed on fixed disease, causing a temporary decrease in
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