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serotonin/sakit kepala
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Method of treating migraine headaches with a highly selective noreoinephrine reuptake inhibitor
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to methods of treating individuals suffering from a variety of conditions wherein inhibiting reuptake of norepinephrine provides a benefit. In particular, the present invention relates to methods of treatment
Method for treating migraine headaches using optically pure S(+) fluoxetine
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BACKGROUND OF THE INVENTION
This invention relates to a novel composition of matter which possesses potent antidepressant activity as a serotonin uptake inhibitor while avoiding the usual detrimental factors, unwanted effects and adverse toxic or psychological effects associated with such agents.
Topical therapy for migraine
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BACKGROUND OF THE INVENTION
Migraine headaches are a debilitating condition in which some 53 million persons per year suffer acute pain. Frequently, migraine is accompanied by sickness and vomiting and a sensitivity to light and noise.
Since the discovery of serotonin (5-hydroxytryptamine, 5-HT)
Topical therapy for migraine
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Applicant hereby claims priority of U.S. patent application Ser. No. 11/999,093 filed Dec. 3, 2007; U.S. patent application Ser. No. 10/163,234, filed on Jun. 5, 2002, which claims the benefit of U.S. Provisional Patent Application No. 60/296,286, filed Jun. 5, 2001, the disclosures of which are
Indole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
Indole derivatives
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This is the national stage under 35 U.S.C. .sctn.371 of application no. PCT/US92/08306 filed Oct. 6, 1992.
BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to
Indole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
Indole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
Indole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
Indole derivatives as 5-HT1 agonists
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This application is a 371 of PCT/US93/01667 filed Mar. 3, 1993.
BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of
Indole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
5-arylindole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to Indole derivatives, intermediates for their preparation, pharmaceutical compositions containing therm, and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other disorders.
U.S. Pat.
Indole derivatives
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SUMMARY OF THE INVENTION
The present invention relates to compounds of the formula ##STR3##
where W is ##STR4##
n is 0, 1, or 2; m is 0, 1, 2, or 3; Y and G are each independently oxygen or sulfur; Z is --O--, --S--, --NH, or --CH.sub.2 ; R.sub.1 is hydrogen, C.sub.1 to C.sub.8 alkyl, substituted
Indole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
Indole derivatives as 5-HT1 agonists
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SUMMARY OF THE INVENTION
The present invention relates to compounds of the formula ##STR3##
where W is ##STR4##
n is 0, 1, or 2; m is 0, 1, 2, or 3; Y and G are each independently oxygen or sulfur; Z is --O--, --S--, --NH, or --CH.sub.2 ; R.sub.1 is hydrogen, C.sub.1 to C.sub.8 alkyl, substituted
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