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Linkage of oxygen deficiency defects and rare earth concentrations in silica glass optical fiber probed by ultraviolet absorption and laser excitation spectroscopy.
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Ultraviolet absorption measurements and laser excitation spectroscopy in the vicinity of 248 nm provide compelling evidence for linkages between the oxygen deficiency center (ODC) and rare earth concentrations in Yb and Er-doped glass optical fibers. Investigations of YAG-derived and solution-doped
Albumin-MnO2 gated hollow mesoporous silica nanosystem for modulating tumor hypoxia and synergetic therapy of cervical carcinoma.
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Currently, some approaches in cancer therapy have gradually shifted from a focus on monotherapy to combined therapy, which results in considerable superadditive therapeutic effects. Herein, bovine serum albumin integrated manganese dioxide nanoparticles (BSA-MnO2) was synthesized via a
Integrating in situ formation of nanozymes with three-dimensional dendritic mesoporous silica nanospheres for hypoxia-overcoming photodynamic therapy.
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Despite great progress in photodynamic therapy (PDT), the therapeutic effect is still limited by some points, such as tumor hypoxia, the short lifetime and the limited action region of 1O2. Herein, a special kind of three-dimensional dendritic mesoporous silica nanosphere (3D-dendritic MSN) was
Gated Mesoporous Silica Nanocarriers for Hypoxia-Responsive Cargo Release.
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Mesoporous silica nanocarriers (MSNs) are appealing in terms of their large cavity surface area and high loading capacity, but they have been suffering from premature cargo release. Herein, we report a gated smart MSN that is sensitive to low oxygen concentration (i.e., hypoxia) via taking advantage
Janus Gold Triangle-Mesoporous Silica Nanoplatforms for Hypoxia-Activated Radio-Chemo-Photothermal Therapy of Liver Cancer.
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Radiation dosage constraints and hypoxia-associated resistance lead to the failure of radiotherapy (RT), especially in hypoxic liver cancer. Therefore, the intricate use of combined strategies for potentiating and complementing RT is especially important. In this work, we fabricated multifunctional
pH/hypoxia programmable triggered cancer photo-chemotherapy based on a semiconducting polymer dot hybridized mesoporous silica framework.
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Although photothermal therapy (PTT) has become a compelling strategy for cancer therapy, few studies concern the physiological consequences of PTT ablation. Herein, we discover that PTT-induced hyperthermia can aggravate tumor hypoxia, which may increase the risk of tumor recurrence and reduce PTT
Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Delivery.
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Hypoxia, or low oxygen tension, is a common feature of solid tumors. Here, we report hypoxia-responsive mesoporous silica nanoparticles (HR-MSNs) with a 4-nitroimidazole-β-cyclodextrin (NI-CD) complex that is acting as the hypoxia-responsive gatekeeper. When these CD-HR-MSNs encountered a hypoxic
Photo darkening of rare earth doped silica.
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The photo darkening (PD) absorption spectra from unseeded amplifier operation (by 915 nm pumping) of ytterbium / aluminum and co-doped silica fibers is after prolonged operation observed to develop a characteristic line at 2.6 eV (477 nm). This line is proposed to be due to inter center excitation
Indole conjugated silica and magnetic nanoparticles as inhibitors of HIF.
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Multifunctional silica nano-vehicles (SiO2@indol-IL) and magnetic nanoparticles (Fe3O4@indol-IL) were constructed through the Schiff bases condensation of indole-3-carboxaldehyde and 4-acetyl-N-allyl pyridinium chloride (ILs) with the amine groups of silica and magnetic nanoparticles. SiO2@indol-IL
A Phosphorescent Iridium(III) Complex-Modified Nanoprobe for Hypoxia Bioimaging Via Time-Resolved Luminescence Microscopy.
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Oxygen plays a crucial role in many biological processes. Accurate monitoring of oxygen level is important for diagnosis and treatment of diseases. Autofluorescence is an unavoidable interference in luminescent bioimaging, so that an amount of research work has been devoted to reducing background
[Lysophospholipids and their diacyl derivatives in rat testicular mitochondria during hypoxia].
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Content of lysophospholipids and their diacyl derivatives was astimated in intact and destructed mitochondria of rat spermatic glands in acute hypoxic hypoxia by means of thin-layer chromatography on silica gel. A ratio of phospholipid lysoforms was found to increase with simultaneous decrease in
Microscopic polyangiitis in a case of silica exposure: a rare presentation.
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A 28-year-old male was admitted for breathlessness, haemoptysis, fever and fatigue. The patient had occupational exposure to silica dust. Arterial blood gas test ABG revealed hypoxemic respiratory failure. Chest CT demonstrated ground glass opacities with interlobular septal thickening and small
Mesoporous Silica-Coated Silver Nanoframes as Drug-Delivery Vehicles for Chemo/Starvation/Metal ions Multimodality Therapy.
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Cutting off the energy supply by glucose oxidase (GOx) to starve cancer cells has been a feasible and efficient oncotherapy strategy. The employment of GOx effectively starves tumor cells by aerobic hydrolysis of glucose, and in turn reconstitutes the tumor microenvironment (TME) by strengthening
ATP depletion and loss of cell integrity in anoxic hepatocytes and silica-treated P388D1 macrophages.
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The relationship between ATP depletion and the loss of cell integrity was examined in the killing of hepatocytes by anoxia and P388D1 macrophages by silica. ATP depletion is a feature of the reaction to either hazard. Treatment of hepatocytes, however, with antimycin, oligomycin, sodium azide, or
Measurement of purines in urine by capillary electrophoresis for estimating the degree of hypoxia in infants.
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We describe a simple, rapid and reproducible method for measuring hypoxanthine, xanthine and uric acid in urine samples of infants by capillary electrophoresis with an uncoated fused silica capillary and ultraviolet detection. Conditions were 40 mmol/l borate buffer pH 9.4 with sodium dodecyl
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