Prostate Cancer

Patients treated for prostate cancer by radical prostatectomy

Visceral adipose tissue specimen

Urology CHRU-TOURS

University Hospital

Uniersity Hospital

Structural Network on Prostate Cancer in the French Greater West Region

Réseau Structurant Sur le Cancer de la Prostate du Grand Ouest

Past dietary intake of essential fatty acids is quantified by measuring their concentration in white adipose tissue

Exposure to persistant organic pollutants (organochlorine chemicals, which are fat-soluble) is quantified by measuring the concentration in white adipose tissue

University Hospital, Tours

Institut National de la Santé Et de la Recherche Médicale, France

Nantes University Hospital

Rennes University Hospital

University Hospital, Angers

Poitiers University Hospital

Centre Hospitalier Universitaire de Pointe-a-Pitre

Consists of 2 subgroups
COPD patients with history of exposure to respirable silica dust
COPD patients with history of exposure to aromatic hydrocarbons

patients with COPD, history of tobacco smoke and no history of occupational exposure
healthy subjects

whole blood, serum,bronchoalveolar lavage fluid

Chronic Obstructive Pulmonary Disease

History of exposure to respirable silica dust due to job

exposure to respirable silica dust

history of exposure to aromatic hydrocarbons due to job

exposure to aromatic hydrocarbons

Novosibirsk City Hospital #2

Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures 2

Molecular, Cytological Features and Genetic Susceptibility of Occupational Chronic Obstructive Pulmonary Disease Attributable to Different Environmental Exposures 2.

Odds ratio and 95% confidence interval will be calculated for each occupational group. Controls - healthy people.

For SNPs that will occur associated with occupational COPD differences in hsCRP and TNFα serum concentration between subjects with different genotypes will be established separately for exposed to dust COPD group and for exposed to chemicals COPD group.

Liubov A Shpagina

Prof., Dr

Siberian Branch of the Russian Academy of Medical Sciences

Consists of 2 subgroups
COPD patients with history of exposure to respirable silica dust
COPD patients with history of exposure to polycyclic aromatic hydrocarbons exhaust

Consists of 2 subgroups
patients with COPD, history of tobacco smoke and no history of occupational exposure
healthy subjects

history of exposure to polycyclic aromatic hydrocarbons exhaust due to job

exposure to polycyclic aromatic hydrocarbons exhaust

Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures

Molecular, Cytological Features and Genetic Susceptibility of Occupational Chronic Obstructive Pulmonary Disease Attributable to Different Environmental Exposures

Step 1 - implantation of everolimus-eluting stent with imaging by MSCT, IVUS and OCT; Step 2 - injection of stem cells containing gold nanoparticles with silica-iron oxide shells.

Coronary Artery Disease

Atherosclerosis

Step 1 - IVUS, OCT-guided put in everolimus-eluting (drug-eluting-DES) stent + intravascular ultrasound (IVUS) mapping + harvesting stem cells with mesenchymal phenotype; Step 2 - culturing of stem cells in medium by gold nanoparticles with silica-iron oxide shells; Step 3 - micro-infusion of stem cells bearing NP into the lesion; Step 4 - detonation of nanoshells after migration of stem cells with NPs inside (until 7-10 days after transplantation). We expect 'melting' and 'burning' effects of PPTT, beneficial effects of bioactive products of stem cells lysis + benefits from further migration of stem cells from patch into the plaque

Stenting and micro-infusion of NP

Put stent in ischemia-related coronary artery by indications for PCI

Implantation of everolimus-eluting stent

Nanocenter of the Ural Federal University

De Haar Research Foundation

Ural Center of Modern Nanotechnologies, Institute of Natural Sciences, Ural Federal University

Ural Institute of Cardiology

Plasmonic Photothermal and Stem Cell Therapy of Atherosclerosis Versus Stenting

Plasmonic Photothermal and Stem Cell Therapy of Atherosclerosis With The Use of Gold Nanoparticles With Iron Oxide-Silica Shells Versus Stenting

Total plaque volume measured by intravascular ultrasound (IVUS), cubic mm.

Composite end-point of all-cause death, all MACE - major cardiovascular events, any revascularization

Analysis of IVUS(intravascular ultrasound)-related composition of plaque (calcified deposits, necrotic calcified core), fibro-lipid core and etc.

Clinical examination of major and minor bleeding under the antithrombotic therapy

Restenosis rate verified clinically + IVUS

Stent thrombosis rate verified clinically, angiography, IVUS

Ultrasound-related examination of coronary flow-mediated vasodilatation

Ultrasound-IVUS-related examination of coronary intima-media thickness

IVUS-related assessment of minimum diameter stenosis

IVUS-related assessment of minimum lumen diameter

silica/nekrosis

Structural Network on Prostate Cancer in the French Greater West Region

Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures 2

Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures

Plasmonic Photothermal and Stem Cell Therapy of Atherosclerosis Versus Stenting

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