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Growth inhibition of sarcoma 180 induced by silica and talc.
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In applying amorphous silica and talc in the site of solid Sarcoma 180 implants, the authors found a suppression and delay of tumor growth which was proveked by peritumoral foreign-body granulomas. Correlating these findings which those experiments which resulted in granulomas of hypersensitivity
Participation of the immune system in regression of a rat Mc7 sarcoma by hyperthermia.
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Participation of the host immune response in eradication of tumor by hyperthermia has been suspected for a long time. The effect of local tumor heating on the immunocompetence of rats bearing Mc7 sarcoma was studied. Following heat treatment of 1- to 1.5-ml foot tumors at 43 degrees for 2 hr,
Enhanced chemotherapy of cancer using pH-sensitive mesoporous silica nanoparticles to antagonize P-glycoprotein-mediated drug resistance.
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Multidrug resistance (MDR) is the major clinical obstacle in the management of cancer by chemotherapy. Overexpression of ATP-dependent efflux transporter P-glycoprotein (PGP) is a key factor contributing to multidrug resistance of cancer cells. The purpose of the present study was to use the
Abrogation of BCG-contact induced tumour inhibition by silica: implications for the mechanism of action.
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The outgrowth of tumours from inocula of syngeneic rat tumour cells injected in admixture with BCG (Glaxo strain) is suppressed, the tumour cells apparently being destroyed in the milieu of the granulomatous reaction to the mycobacteria. The possible candidacy of macrophages as the major "effector
Effector mechanisms against Rous sarcomas in quail.
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The inhibitory effect on tumor growth of thymus-derived cells in the avian virus system has been demonstrated by several investigators. Here we report two kinds of experiments performed to test the role of various potential effector cells in the immune response against Rous sarcomas. In vivo
In vivo distribution and antitumor activity of doxorubicin-loaded N-isopropylacrylamide-co-methacrylic acid coated mesoporous silica nanoparticles and safety evaluation.
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The objective of this study was to develop and evaluate the antitumor activity and the safety of a delivery system containing mesoporous silica nanoparticles (MSN) coated with pH-responsive poly (N-isopropylacrylamide-co-methacrylic acid; P NIPAM-co-MAA) for doxorubicin (DOX) delivery (P-MSN-DOX) in
Isolation of an SV40 induced sarcoma transformation associated antigen.
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A transformation associated antigen was isolated from an SV40 induced hamster sarcoma by sequential silica gel column chromatography and preparative silica gel 60 thin layer chromatography after tissue extraction with chloroform:methanol (2:1, v/v). It migrated with an rf of 0.21 on silica gel 60
THE ISOLATION AND PARTIAL CHARACTERIZATION OF THE GLYCOLIPIDS OF BP8/C3H ASCITES-SARCOMA CELLS.
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1. The total lipid was extracted from BP8/C3H ascites-sarcoma cells with acetone, light petroleum, pyridine and chloroform-methanol successively. Each extract was treated with mild alkali. The alkali-stable lipids from the pyridine and chloroform-methanol extracts, which included the glycolipids,
Factors affecting passive monoclonal antibody therapy of Moloney sarcoma in BALB/c mice.
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We have developed a syngeneic monoclonal antibody (MoAb) (244-19A) which retards growth and contributes to cures of BALB/c mice bearing Moloney sarcoma cell (MSC) tumors (S.J. Kennel, T. Lankford, and K.M. Flynn, Cancer Res., 43: 2843-2847, 1983). The 244-19A epitope has not been detected in normal
MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica.
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Dendritic cells (DCs) are specialized first-line sensors of foreign materials invading the organism. These sentinel cells rely on pattern recognition receptors such as Nod-like or Toll-like receptors (TLRs) to launch immune reactions against pathogens, but also to mediate tolerance to self-antigens
Genes of chicken MHC regulate the adherence activity of blood monocytes in Rous sarcomas progressing and regressing lines.
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The influence of the chicken major histocompatibility (B) complex (MHC) on the adherence potential of monocyte-derived macrophages was examined using the congenic chicken lines CB and CC. These lines represent well-defined genetic models for the study of resistance (CB) or susceptibility (CC) to the
Contribution of myeloid and lymphoid host cells to the curative outcome of mouse sarcoma treatment by photodynamic therapy.
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Selective depletion or inactivation of specific myeloid populations (neutrophils, macrophages) and lymphoid populations (helper T cells, cytolytic T cells) in EMT6 sarcoma-bearing mice was used to determine the contribution of each of these host immune cell types to the curative outcome of
Antitumor and antitumor-promoting actions of macrophages and their relationship with estrogen.
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Silica provides, in fact, a remarkable example of selective toxicity for macrophage by a substance of simple chemical composition and low chemical reactivity. Intraperitoneal injection of silica resulted in an increase of growth rate of subcutaneously implanted mouse sarcoma 180 (S180) in female
Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities.
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Gilvocarcin V and gilvocarcin M, a group of antitumor antibiotics with a novel skeleton, were discovered in culture broths of Actinomycete DO-38. The producing organism, subsequently determined to be a new species and named Streptomyces gilvotanareus (NRRL 11382). Gilvocarcin V and M were isolated
Inhibition of growth and metastasis of syngeneic transplantable tumours by an aromatic retinoic acid analogue. 2. T cell dependence of retinoid effects in vivo.
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An aromatic retinoic acid analogue (Ro 10-9359) previously shown to be capable of inhibiting the growth and metastasis of immunogenic sarcomas and carcinomas (see accompanying paper) was tested for its anti-tumour effects in various categories of immune-deprived mice. 'Non-specific'
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