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Styrene maleic acid copolymer-pirarubicin induces tumor-selective oxidative stress and decreases tumor hypoxia as possible treatment of colorectal cancer liver metastases.
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BACKGROUND
Pirarubicin, a derivative of doxorubicin, induces tumor destruction via the production of reactive oxygen species (ROS) but is associated with cardiotoxicity. As a macromolecule (conjugated to styrene-maleic acid [SMA]), SMA-pirarubicin is selective to tumors resulting in improved
Toxicity of styrene vapor in hepatocyte monolayers at low oxygen tensions.
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Hepatocyte monolayer cultures were exposed to 6000 ppm styrene vapor at 20%, 2%, or 1% O2 and assayed for signs of cell damage immediately following the 2-hr exposure and then 24 hr later. Oxygen concentrations were used that were previously shown to maximize lipid peroxidation and to predispose
Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli.
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Human cytochrome P450 2S1 was recently identified and shown to be inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin and hypoxia. It is highly expressed in epithelial cells of tissues that are exposed to the environment and in many tumors of epithelial origin. The biological function of CYP2S1 has not
Arterial system of the gill of the lobster, Homarus americanus.
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Three-dimensional architecture of the branchial artery and venous vasculature of Homarus americanus was studied by the method of corrosion cast or styrene cracking and by scanning electron microscopy. Four arteries, the epibranchial (EA) and hypobranchial arteries (HA) on the septal wall of the
[Ontogenetic characteristics of the body response to chronic exposure to chemical substances].
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Chronic intoxication by carbon oxide and long-term exposure to hypoxic hypoxia produced more favourable reactions in animals, exposed to these in the early terms of ontogenesis. The observed regularity was not found under chronic exposure to styrene and epichlorohydrin ++. A supposition is made on
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