gammaCore sham device which will not provide stimulation of the vagus nerve

Active gammaCore device that supplies non-invasive stimulation of the cervical branch of the Vagus nerve

Subarachnoid Hemorrhage, Aneurysmal

The intervention consists of a transcutaneous non-invasive stimulation of the cervical branch of the vagus nerve (nVNS) using gammaCore, an FDA approved device for the treatment of migraine and cluster headache. This will be compared to the sham device, which is the same device which will not provide stimulation to the nerve. Stimulation frequency will be identical to the frequency used in previous nVNS studies for the treatment of migraine headache.

gammaCore

Northshore University Hospital

Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage

Daily morphine equivalence dosage will be calculated and compared between the active and Sham group

Headache intensity is measured every 4 hours per standard of care. The pain intensity is reported using a 0 to 10 numeric rating scale, o being no pain, and 10 being severe pain. The mean daily headache intensity will be measured and compared between the active and sham group

The rate of opiate related adverse events such as urinary retention, constipation, respiratory depression, central nervous system depression will be compared between the 2 groups

Tania Rebeiz

Assistant Professor, MD

Northwell Health

In this study, Kinesio Tape Tex Gold® kinesio tape over lateral ankle (5cm*5m) is used. 36 participants were taped for the TTH.50-mm wide and 0.5-mm thick KT was applied to the upper trapezius muscle with one I-shaped tape. The tape was measured from the acromion to the hairline at the back, and the upper trapezius fibers were extended in the extended position, ie the cervical vertebrae were flexed to the opposite side and applied to the same side in the flexion and rotation position.

Upper trapezius muscle stretching exercise was applied to the control group.

Tension-Type Headache

Upper trapezius muscle stretching exercise with Kinesio taping (KT) was applied to the study group. KT was applied 8 times in total for 4 weeks with 2 sessions per week. Stretching exercise was done in the morning, afternoon and evening 3 times (repeated 10 times per set) every day for 4 weeks and 5 days of the week.

Kinesio taping

Exercise

Tomris Duymaz

Efficacy of Kinesio Taping in Tension Type Headache

Efficacy of Kinesio Taping on Pain, Pain Threshold and Emotional Status in Tension Type Headache

The algometer is a mechanical pressure device with a minimum diameter of 100 g and a pressure of 10 kg / cm2, with a spring-loaded cylinder with a rubber tip, a circle and a pressure surface of 1 cm2 in diameter, obtained in kg / cm2. Before measuring with the algometer, a pressure of approximately 4 kg was applied to the midpoint of the upper part of the trapezius muscle, which is the control point, with the pulp of the thumb of the hand. Then the force was applied to the same point, causing pain to separate the patient's sense of pressure and pain sensation. This process has been repeated several times. Measurements with an algometer were made at a rate of 1 kg per second. The measurements were interrupted for at least 15-20 seconds. Three measurements were made at these 2 sensitive points and the average of the measurements was recorded.

Visual Analog Scale (VAS) is used to convert some numerical values, such as pain, to numeric values. The two extremes of a 100 mm line are to be assessed on two extremes and the patient is asked to indicate on the line where the severity of the pain is appropriate by drawing a line or placing a point or pointing. The length of the distance from where the pain has never occurred to the point the patient has marked indicates the pain of the patient

Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) developed by Aron T. Beck in 1961, Turkish validity and reliability were done by Hisli N. Emotional state assessment scale that measures the characteristic attitude and depression symptoms. The application takes about 10-15 minutes to complete. It is designed for people aged 13 and over. Scoring and evaluation of scales is easy. The total number of points counted from each four-sentence sentence group is found. For depression scale; 0-9: Normal level, 10-16: Mild depression, 17-29: Moderate depression, 30-63: Indicates severe depression. For anxiety scale; Normal range between 0-7 points, mild anxiety between 8-15 points, middle anxiety between 16-25 points, and severe anxiety between 26-63 points

TOMRIS DUYMAZ

Principal Investigator

Istanbul Bilgi University

Patients were randomly divided into 2 groups. A randomized list is prepared in a computer environment by a statistician for randomization. In this list, the odd numbers for the control group and the KT group were given double numbers. The group identification is printed on sequentially numbered cards placed in sealed envelopes. After enrollment, the numbered envelope was opened by the patient and the blind investigator.

Subjects who will be administered 200 micrograms of nitroglycerin once into branches of their external carotid artery to determine the role of dilation of this artery to cause migraine-like pain

Migraine Disorders

Migraine, Classic

Migraine Without Aura

Intra-arterial adminstration to dilate external carotid artery branches to replicate migraine pain

Nitroglycerin

Montefiore Medical Center

Understanding the Pathophysiology of Migraine Pain

Understanding the Role of the External Carotid Artery in the Pathophysiology of Migraine Pain

The reporting of migraine-like pain after nitroglycerin administration

Severity of migraines for 2 weeks prior to angiogram

Frequency of migraines for 2 weeks prior to angiogram

Quality of migraines for 2 weeks prior to angiogram

Location of migraines for 2 weeks prior to angiogram

Alleviating factors of migraines for 2 weeks prior to angiogram

Aggravating factors of migraines for 2 weeks prior to angiogram

Associated symptoms of migraines for 2 weeks prior to angiogram

Therapies utilized for migraines for 2 weeks prior to angiogram

Enlargement of the diameter of the vessel of interest after nitroglycerin administration

Relief of induced migraine pain with temporary balloon occlusion of the dilated artery. Standard pain medication will also be available for treatment

Monitoring for retroperitoneal hematoma, vascular injury, infection, contrast reaction, worsening contralateral headache symptoms, new neurologic deficit peri-procedurally until discharge

Severity of migraines for 2 weeks post-angiogram

Frequency of migraines for 2 weeks post-angiogram

Quality of migraines for 2 weeks post-angiogram

Location of migraines for 2 weeks post-angiogram

Alleviating factors of migraines for 2 weeks post-angiogram

Aggravating factors of migraines for 2 weeks post-angiogram

Associated symptoms of migraines for 2 weeks post-angiogram

Therapies utilized for 2 weeks after angiogram until follow-up clinic visit

subarachnoid hemorrhage/muntah

Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage

Efficacy of Kinesio Taping in Tension Type Headache

Understanding the Pathophysiology of Migraine Pain

Database tanaman obat terlengkap yang didukung oleh sains