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Activation of acetyl-coenzyme A carboxylase is involved in Taxol-induced ovarian cancer cell death.
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Acetyl-coenzyme A carboxylase (ACC) is an attractive target for research into the treatment of a variety of human diseases, including diabetes, obesity and cancer. Mounting evidence suggests that the inhibition of ACC induced of cancer cell apoptosis. However, whether the inhibition of ACC regulates
Breast cancer and obesity: in vitro interferences between adipokines and proangiogenic features and/or antitumor therapies?
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Obesity is now considered as a risk factor for breast cancer in postmenopausal women. Adipokine levels are modulated in obesity, and may play a role in carcinogenesis. Moreover, obesity increases risk of cancer mortality. Here, we hypothesized that this increase could be due to a modification in
Leptin contributes to the taxol chemoresistance in epithelial ovarian cancer.
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Epithelial ovarian cancer (EOC) is a gynecological malignancy with high morbidity. Treating EOC remains a challenge, as the pathogenesis of this disease remains unclear and chemoresistance is a common occurrence. A number of previous studies have revealed that obesity is closely associated with
An assay to measure angiogenesis in human fat tissue.
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BACKGROUND
Inhibition of angiogenesis reverses rodent obesity. A validated assay in human fat tissue is needed to study the role of angiogenesis in human obesity.
METHODS
Human fat tissue fragments from surgery were placed in 96-well plates, embedded in fibrin thrombin clot and overlaid with cell
Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism.
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Several herbal plants improve medical conditions. Such plants contain many bioactive phytochemicals. Terpenoids (also called "isoprenoids") constitute one of the largest families of natural products accounting for more than 40,000 individual compounds of both primary and secondary metabolisms. In
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