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Ifosfamide-induced encephalopathy in patients with uterine sarcoma.
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OBJECTIVE
To report two cases of recurrent uterine sarcoma that developed ifosfamide-induced encephalopathy (IIE) with successful management.
METHODS
The patient in the first case developed grade 4 toxicity and had a partial response after the fourth dose of intravenous methylene blue was
Evaluation of methylene blue, thiamine, and/or albumin in the prevention of ifosfamide-related neurotoxicity.
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CONCLUSIONS
A serious adverse effect that can limit the utility of ifosfamide is neurotoxicity, known as ifosfamide-induced encephalopathy (IIE). Information regarding the usefulness of prophylactic administration of methylene blue, thiamine, and albumin to reduce the incidence of IIE is scarce. We
Fatal high-grade skull osteosarcoma 30 years following radiotherapy for Cushing's disease
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Summary: Cushing's disease is a rare disorder characterised by excessive cortisol production as a consequence of a corticotroph pituitary tumour. While the primary treatment is surgical resection, post-operative radiation therapy may be
[Transketolase activity and the TDP effect in tissues of animals with experimental tumors].
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Activity of transketolase and the TDP-effect were studied in blood and liver subcellular fractions of mice with Erlich ascites carcinoma and of rats with sarcoma 45 which were maintained on a synthetic diet containing either all the vitamins or devoid of thiamine. As compared with other mice liver
Antitumor activity of hydroxythiamine and methotrexate immobilized on monocarboxycellulose.
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The aim of the present study was to examine the antitumor and antivitamin activities of some new combinations of methotrexate (MT) and hydroxythiamine (HT), antagonists of folic acid and thiamine, respectively, immobilized on monocarboxycellulose (MCC). Ehrlich ascites carcinoma and sarcoma 180 were
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