Novel androgens having one or more substituents providing radical trapping properties are disclosed as useful in methods of treating androgen deficiency in man, benign prostate hypotropy and carcinoma of the prostate, osteoporosis, vascular disease-induced or ischemically-induced cerebral edemas, subarachnoid hemorrhages, ischemic shock, cerebral insult, Parkinson's disease and Alzheimer's disease. The androgen compound used for treating androgen deficiency in man has a steroid ring with an .alpha.-tocopherol group or a trolox group substituent.

Jenapharm GmbH

Androgens and anabolic agents

It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the active ingredient a substance selected from among farnesol, a farnesol derivative, a tocopherol derivative, a tocotrienol derivative, pharmacologically acceptable salts thereof and solvates thereof, the above-described inhibitor of ischemic disorders can exert therapeutic and preventive effects on diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof (for example, brain infarction, brain edema, cardiac infarction, etc.) not only by the administration in the acute ischemic stage but also by the therapeutic administration in subacute and/or chronic stages after ischemia-reperfusion. It is also intended to provide a farnesol carboxylic acid ester derivative and a method of producing the same.

Fukuoka University

Inhibitor of ischemic disorders

An improved skin cream composition according to the present invention provides protection against lumpiness, edema, and other effects of liposuction and cosmetic surgery, as well as increasing the smoothness of the skin. In general, a skin cream composition according to the present invention comprises: water, and emulsified and dispersed in the water: (1) a long-chain fatty acid ester of ascorbic acid; (2) a short-chain carboxylic acid ester of tocopherol; (3) a glyceryl ester complex comprising at least one glyceryl ester selected from the group consisting of glyceryl linoleate, glyceryl linolenate, and glyceryl arachidonate; (4) a first complex consisting essentially of water, propylene glycol, lecithin, caffeine benzoate, and palmitoyl carnitine; (5) a second complex consisting essentially of water, caffeine, carnitine, and hydrolyzed glycosaminoglycans; (6) a third complex consisting essentially of glycerol, butcher broom extract, passion flower extract, glycogen, hydrolyzed collagen, and PEG 6-32; (7) calendula extract; (8) a water-glycol extract of chamomile; (9) hydrophilic microcapsules; (10) lipophilic microcapsules; and (11) microcapsules comprising methylsilanol elastinate. Other, optional cosmetic ingredients and ancillary ingredients can also be used.

tocopherol/sembap

Androgens and anabolic agents

Inhibitor of ischemic disorders

Skin cream composition

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