ursolic acid/atrofi

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Effects of ursolic acid on muscle mass and bone microstructure in rats with casting-induced muscle atrophy.

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Recent studies suggest that ursolic acid (UA) is a potential candidate for a resistance exercise mimetic that can increase muscle mass and alleviate the deleterious effect of skeletal muscle atrophy on bone health. However, these studies evaluated the effects of UA on skeletal muscle

Concurrent treatment with ursolic acid and low-intensity treadmill exercise improves muscle atrophy and related outcomes in rats.

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The objective of this study was to analyze the concurrent treatment effects of ursolic acid (UA) and low-intensity treadmill exercise and to confirm the effectiveness of UA as an exercise mimetic to safely improve muscle atrophy-related diseases using Sprague-Dawley (SD) rats with skeletal muscle

Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice.

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The purpose of this study was to assess the effects of low-dose ursolic acid (UA) on glycemic regulation and immune responses in streptozotocin-nicotinamide (STZ/NA)-induced diabetic mice. Diabetic mice were supplemented with two different doses of UA (0.01 and 0.05%, w/w) or metformin (0.5%, w/w)

Nephroprotective effect of ursolic Acid in a murine model of gentamicin-induced renal damage.

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The present study evaluates the nephroprotective effects of ursolic acid in a murine model of gentamicin induced renal damage. Wistar albino rats of either sex, weighing 150-200 g were divided into 5 groups; normal saline, gentamicin 80 mg/kg, intraperitoneally for 8 days, ursolic acid at 2, 5, and

MECHANISTIC EVALUATION OF URSOLIC ACID AGAINST ROTENONE INDUCED PARKINSON'S DISEASE- EMPHASIZING THE ROLE OF MITOCHONDRIAL BIOGENESIS.

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Parkinson's disease (PD) is an age associated, progressive, second most common neurodegenerative disease, caused due to degeneration of dopaminergic neurons in the substantia nigra (SN). Various studies imply mitochondrial dysfunction, oxidative stress, altered degradation of misfolded proteins in

Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats.

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This study assessed the effects of ursolic acid (UA) on airway-vessel remodeling and muscle atrophy in cigarette smoke (CS)-induced emphysema rats and investigated potential underlying mechanisms.Emphysema was induced in a rat model with 3 months of CS

Ursolic acid derivative ameliorates streptozotocin-induced diabestic bone deleterious effects in mice.

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OBJECTIVE This study was performed to investigate bone deteriorations of diabetic mice in response to the treatment of ursolic acid derivative (UAD). METHODS The biomarkers in serum and urine were measured, tibias were taken for the measurement on gene and protein expression and histomorphology

Ursolic acid ameliorates aging-metabolic phenotype through promoting of skeletal muscle rejuvenation.

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Ursolic acid (UA) is a lipophilic compound, which highly found in apple peels. UA has some certain features, of the most important is its anabolic effects on skeletal muscles, which in turn plays a prominent role in the aging process, encouraged us to evaluate skeletal muscle rejuvenation. This

Effects of ursolic acid on sub-lesional muscle pathology in a contusion model of spinal cord injury.

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Spinal Cord Injury (SCI) results in severe sub-lesional muscle atrophy and fiber type transformation from slow oxidative to fast glycolytic, both contributing to functional deficits and maladaptive metabolic profiles. Therapeutic countermeasures have had limited success and muscle-related pathology

Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy.

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OBJECTIVE Here, we discuss a recently developed experimental strategy for discovering small molecules with potential to prevent and treat skeletal muscle atrophy. RESULTS Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression, which generate complex but measurable

Ursolic acid in health and disease.

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Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. There is a growing interest in UA because of its beneficial effects, which include anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-carcinogenic effects. It exerts these effects in various tissues and

[Effects of ursolic acid on liver injury and its possible mechanism in diabetes mellitus mice].

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OBJECTIVE To study the effects of ursolic acid on liver injury in diabetic mice induced by high-fat diet combined with streptozotocin(STZ), and to explore its possible mechanisms. METHODS Diabetes mellitus was induced in twenty male ICR mice by a combination of high-fat diet for 6 weeks with

[Study on the protective effect of ursolic acid on alloxan-induced diabetic renal injury and its underlying mechanisms].

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OBJECTIVE To investigate the effect of ursolic acid (UA) on the alloxan-induced kidney injury in diabetic mice and explored its possible mechanisms. METHODS Diabetes mellitus was induced in male Kunming mice by an injection of alloxan (70 mg/kg, i.v.). After 72 hours, blood glucose levels were

Loquat (Eriobotrya japonica) extract prevents dexamethasone-induced muscle atrophy by inhibiting the muscle degradation pathway in Sprague Dawley rats.

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In the Orient, loquat (Eriobotrya japonica) extract (LE) is widely used in teas, food and folk medicines. The leaves of the loquat tree have been used for generations to treat chronic bronchitis, coughs, phlegm production, high fever and gastroenteric disorders. One of the major active components of

mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass.

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Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by fasting in both human and mouse muscle, and 29 mRNAs that were regulated by both fasting and spinal cord injury in human

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