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vincristine/seizures
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Cardiac arrest and possible seizure activity after vincristine injection.
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OBJECTIVE
A case of cardiac arrest and possible seizure activity after vincristine injection in a child is reported.
CONCLUSIONS
A two-year-old African-American girl with stage IV hepatoblastoma arrived at a clinic to receive her fourth dose of vincristine as part of standard induction therapy. The
Posaconazole-vincristine coadministration triggers seizure in a young female adult: a case report.
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Coadministration of azoles and vincristine has been shown to increase vincristine neurotoxic effects due to the inhibition of cytochrome P450 (CYP) isoform 3A4, for which vincristine is a substrate. Despite the absence of any casual relationship between seizure and coadministration of azoles, few
Unilateral seizures following vincristine intravenous injection.
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A case of acute central nervous system toxicity following the intravenous injection of vincristine was observed in a patient treated with a chemotherapy regimen including cyclophosphamide, doxorubicin and prednisone for non-Hodgkin lymphoma. The neurological symptoms consisted of right-sided
Reversible encephalopathy and seizures as a result of conventional vincristine administration.
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An 8-year-old child with acute lymphoblastic leukemia (ALL) developed seizures associated with bilateral lucencies on CT scan during standard induction therapy with vincristine and prednisone. Because of the progressive nature of her symptoms, a brain biopsy was performed and revealed neurotubular
Vincristine-induced seizure potentiated by itraconazole following RCHOP chemotherapy for diffuse large B-cell lymphoma.
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OBJECTIVE
To report the case of a patient with diffuse large B-cell lymphoma (DLBCL) who developed vincristine (VCR)-induced seizure after R-CHOP chemotherapy.
METHODS
A 22-year-old boy with DLBCL developed generalized tonic clonic seizures following R-CHOP chemotherapy. After receiving the third
Vincristine-induced acute life-threatening hyponatremia resulting in seizure and coma.
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We report a case of a four-year-old boy with stage 1 Wilms tumour, who developed Vincristine-induced acute life- threatening hyponatremia, which presented as generalized tonic clonic seizures and coma. He was intubated and mechanically ventilated. There were no localizing neurological signs. CSF
[Severe neurological toxicity (coma, convulsions, distal motor neuropathy) secondary to the association of accidental poisoning by isoniazid and a protocol containing high doses of vincristine].
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Authors report the case of a 19 year old metastatic Ewing's sarcoma, prophylactically treated for suspected tuberculosis by Rifampicin and INH. Hepatic failure was induced by accidental overdose of INH. A high dose containing VCR protocol associated, lead to a coma with convulsions and severe motor
Letter: Coma and convulsions associated with vincristine therapy.
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Seizures associated with vincristine sulfate therapy.
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[Cerebral convulsions and acute psychosyndrome following vincristine therapy].
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[Paralytic ileus, convulsions and hyponatremia during vincristine treatment. Observations on a case in a young girl with acute lymphocytic leukemia].
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[Generalised clonic seizure associated with vincristine in a pediatric case].
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Seizures as an adverse drug reaction after therapeutic dose of vincristine.
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Overdosage with vincristine.
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Five patients received overdoses of vincristine ranging from 3.5 to 32 mg. Neurotoxicity accounted for most of the complications observed. Peripheral neuropathies, cranial nerve palsies, paralytic ileus, atony of the bladder, hypertension, hypotension, seizures, inappropriate ADH secretion, and
Posaconazole-increased vincristine neurotoxicity in a child: a case report.
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A 9-year-old girl was managed according to the COPRALL 04 protocol for treatment of a relapse of acute lymphoblastic leukemia. Owing to a previous case of disseminated fusariosis, posaconazole was started 5 days before initiation of chemotherapy. Six days after the last dose of vincristine, the
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