To determine the prevalence and severity of vitamin D deficiency and glucose tolerance in persons with chronic SCI.

Vitamin D3 Supplementation and Pulmonary Function:
To determine the relationship between levels of vitamin D and overall pulmonary function, as measured by PFTs (spirometry and body plethysmography).
To determine effects of vitamin D supplementations on overall pulmonary function and selected biomarkers of inflammation (FeNO, pH, 8- isoprostane levels).

Vitamin D3 Supplementation and Endocrine Function:
To determine the effect of vitamin D replacement therapy on carbohydrate metabolism and insulin resistance in persons with vitamin D deficiency (<20ng/ml) and IGT, mild DM (e.g. fasting serum glucose <140 mg/dL) and/or IR.

Spinal Cord Injury

Vitamin D Deficiency

Vitamin D3

Spinal Cord Damage Research Center website

James J Peters VA Medical Center

Vitamin D Deficiency and Replacement on Pulmonary and Endocrine Function in SCI

Effects of Vitamin D Deficiency and Its Replacement on Pulmonary and Endocrine Function in Persons With SCI

Vitamin D levels will be obtained during screening.

Pulmonary function change will be measured in vitamin D deficient SCI subjects by spirometry and body plethysmography at baseline, 3 months, and 6 months.

Pulmonary function change will be measured in vitamin D deficient SCI subjects by biomarkers of inflammation, such as FeNO, pH, and 8-isoprostane, at baseline, 3 months, and 6 months.

Vitamin D deficient SCI subjects with IGT and/or IR will undergo vitamin D replacement therapy. Glucose and insulin levels will be measured at baseline, 3 months, and 6 months.

Vitamin D deficient SCI subjects will complete a pain survey at baseline, 3 months, and 6 months to assess musculoskeletal pain and how it may improve with vitamin D supplementation.

William A. Bauman, M.D.

Research Center Director

James J. Peters Veterans Affairs Medical Center

HIV Seropositivity

Hopital Lariboisiere

Fluoride Metabolism, Bone Remodelling and Mineral Density in HIV Patients Treated With Tenofovir +/- Emtricitabine

Comparative Study of Fluoride Metabolism, Bone Remodelling and Mineral Density in HIV + Men Being Given Tenofovir With FTC, Emtricitabine (TRUVADA®), or Without (VIREAD®), as Part of Their Antiretroviral Therapy.

Célia Lloret-Linares, MD PhD

Professor, Medicine A Department,

Hopital Lariboisière

Vitamin D (D-cure) will be administered by monthly oral intake. During a prospective follow-up period of one year, the patients will get the normal care with some additional tests for the study.

Placebo will be administered by monthly oral intake. During a prospective follow-up period of one year, the patients will get the normal care with some additional tests for the study.

vitamin d deficiency/protease

Vitamin D Deficiency and Replacement on Pulmonary and Endocrine Function in SCI

Fluoride Metabolism, Bone Remodelling and Mineral Density in HIV Patients Treated With Tenofovir +/- Emtricitabine

Vitamin D as Treatment for Chronic Obstructive Pulmonary Disease (COPD)

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