Influence of a beta-adrenoceptor stimulant, KWD 2131, in nasal histamine provocation tests. Rhinomanometric evaluations in normal persons and patients with hay fever.

Nasal histamine provocation was performed in ll asymptomatic (out of season) patients with hay fever and in ll normal controls. Posterior rhinomanometry was used for objective evaluation. The histamine challenges caused nasal symptoms as well as increased nasal airway resistance. The differences in response between the two groups of subjects were not significant. KWD 2131, a beta-adrenoceptor-stimulating drug which was ascribed an antiallergic effect in a previous allergen provocation study, did not block the effects of histamine challenge in a randomized, placebo-controlled, double-blind, crossover evaluation. The absence of protective action against histamine-induced effects with KWD 2131, supports a mast-cell-stabilizing effect of the substance in allergen provocation.