Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 2011-Mar
[Studies on the chemical constituents of Coleus forskohlii transplanted in Tongcheng and their antitumor activity].
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OBJECTIVE
To study the chemical constituents of Coleus forskohlii.
METHODS
Isolation and purification were carried out by silica gel column chromatographic and Toyopearl HW-40F. Compounds were identified and elucidated by spectral and chemical methods.
RESULTS
Seven compounds were obtained from ethyl acetate extract fraction. Their structures were identified as lupeol (1), oleanolic acid (2), uvalo(3), beta-sitosterol (4), colonic acid (5), demethylcryptojaponol (6), coleolic acid (7). Compounds 1, 2, 6, 7 showed obviously antitumor activity.
CONCLUSIONS
Compound 1 and 3 are isolated from the genus for the first time. Moreover, compound 1 is firstly found to have antitumor activity from the plants.
