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Effect of Aframomum melegueta. Seed Extract on Castor Oil-Induced Diarrhea.

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The effect of the aqueous (aq) seed extract of Aframomum melegueta. K. Schum. (Zingiberaceae) on castor oil-induced diarrhea, intestinal fluid secretion, and gastrointestinal transit was investigated in the study. Castor oil (10 ml/kg, p.o.) induced copious diarrhea in all rats 3 h after treatment.

Nonsteroidal, antiinflammatory drug-induced gastrointestinal injuries and related adverse reactions: epidemiology, pathogenesis and management.

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A large proportion of the population all over the world consumes acetylsalicylic acid (ASA: aspirin) or other nonsteroidal, antiinflammatory drugs (NSAIDs). This is associated with a considerable morbidity and mortality. Elderly patients, patients with prior history of peptic ulcer disease (PUD) or

Endocarditis in a cow.

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Bacterial endocarditis of the tricuspid valve was diagnosed in a cow with weight loss, reduced milk production, and intermittent fever. Clinical signs of disease included jugular and mammary vein pulses, tachycardia, large cardiac silhouette, and grade-III/V holosystolic murmur. The diagnosis was

Pharmacological properties of droxicam, a new non-steroidal anti-inflammatory agent.

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Droxicam showed high antiinflammatory activity in carrageenin-induced edema in rat. At doses of 0.25 and 0.5 mg/kg, droxicam was as active as piroxicam and more active than phenylbutazone given at 2.5 and 5 mg/kg. Against nystatin-induced edema, droxicam (ED50, p.o., 5, 6, 7, 8 h: 7.5, 12.9, 4.8,

Lymphocytic and collagenous colitis: the emerging entity of microscopic colitis. An update on pathophysiology, diagnosis and management.

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Microscopic colitis (MC) encompasses the two morphologically distinct entities of collagenous colitis (CC) and lymphocytic colitis (LC). MC was first described less than 30 years ago but is presently recognized as a relatively common cause of chronic diarrhea in the adult population. Remarkably, up

Severe coagulopathy after a bite of a green bush viper (Atheris squamiger): case report and biochemical analysis of the venom.

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A 34 year old male bitten by an adult Atheris squamiger snake developed symptoms of nausea, vomiting, diarrhea which were followed by drowsiness and impaired breathing. Local hemorrhage, edema and pain at the bite-site occurred, but no systemic bleeding or hemorrhagic diathesis developed. All

Cilostazol Can Increase Skin Oxygen Supply Assessed by Transcutaneous Oxygen Pressure Measurement in Type 2 Diabetes With Lower Limb Ischemic Disease: A Randomized Trial.

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OBJECTIVE The purpose of this study was to compare the efficacy and safety of cilostazol versus acetylsalicylic acid (ASA) for amelioration of lower limb ischemia in type 2 diabetes. METHODS Prospective, randomized positive-controlled open clinical trial. METHODS Eighty-nine patients with type 2

Perianal Crohn's disease.

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A 13-year-old girl with a history of 4 months of perianal skin lesions is described. Physical examination revealed three 0.5 I 1-cm red, swollen, fleshy, skin tags extending from the perianal area to the perineum (Fig. 1). The patient reported intermittent fever, diarrhea, and abdominal pain, and

Clinical correlation of mesenteric vascular disease in older patients.

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Mesenteric vascular obstruction is difficult to characterize, since it may produce differing acute or chronic clinical pictures and various organic symptoms, such as ischemic colitis and abdominal angina. The diagnosis of chronic mesenteric ischemia (CMI) is thus still mainly based on historic

[Newly recognized side-effects of proton pump inhibitors. Arguments in favour of fundoplication for GERD?].

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Among other indications proton pump inhibitors (PPIs) are used as medical treatment of gastroesophageal reflux disease (GERD) and are the most frequently prescribed and most frequently used drugs in gastroenterology. Until recently PPIs were regarded as very safe and associated with very few

The efficacy and safety of intramuscularly administered 15(S) 15 methyl prostaglandin E2 methyl ester for induction of artificial abortion.

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The practicability of an intramuscular dose schedule of 10 mug of 15(S) 15 methyl prostaglandin E2 methyl ester [15(S) Me PGE2] administered every 4 hours was evaluated in 42 subjects from 7 to 20 menstrual weeks' gestation. Half of the subjects served as controls (Group I) and half of the subjects

[Systemic mastocytosis: clinical case].

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We report a 38 years old female who, since her childhood, had a history of precisely limited, fixed maculo papular dark brown cutaneous lesions in the trunk and extremities. These lesions become erythematous or urticarial after rubbing, medication intake or scratching. She also had frequent episodes

Traveler's myopericarditis.

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Colitis caused by Shigella is an uncommon etiology of infectious diarrhea in developed countries, usually presenting as traveler's diarrhea. Aside from clinical intestinal manifestations, shigellosis can present with a wide variety of extra-intestinal symptoms. We present the case of a 38-year-old

Steroid therapy for inflammatory bowel disease.

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In inflammatory bowel disease (IBD) as represented by ulcerative colitis (UC) and Crohn's disease (CD), UC is characterized by the diffuse inflammation from rectum and the resulting frequent diarrhea and bloody stool, and CD is characterized by scattered inflammation that may affect any part of the

[Diagnosis and treatment of Crohn's disease in children: 10 years' clinical experience].

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OBJECTIVE To enhance our understanding of pediatric Crohn's disease and improve diagnostic accuracy and therapeutic efficacy by characterizing the clinical picture and reviewing 10 years' clinical experience in diagnosis and treatment. METHODS Nine cases with active Crohn's disease diagnosed between

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