Particular naturally occurring glycosylated acyl-flavonols are now shown to be effective mammalian .alpha.-amylase inhibitors. Such compounds can be obtained from plants of the genus Crocosmia and the compounds are useful in controlling starch digestion such as for management of glycemia in pre-diabetic or diabetic subjects, for management of obesity or for inhibiting oral caries or plaque formation.

Withers; Stephen

Tarling; Andrew C.

Andersen; Raymond

Brayer; Gary D.

Woods; Katherine

The University of British Columbia

Alpha-amylase inhibitors: the montbretins and uses thereof

A dental plaque-degrading composition containing endodextranase produced by Arthrobacter globiformis W31 exhibiting high degradation efficacy to insoluble glucan produced by Streptococcus mutans IFO 13955, the dental plaque-degrading composition additionally containing .alpha.-amylase of various origins. These compositions are useful for preventing the settlement of Streptococcus mutans in the oral cavity and the formation of new dental plaque and for preventing the dental caries, and provided in the form of dentifrices, denture detergents, troches, mouth washes, chewing gums or candies.

Nakano Vinegar Co., Ltd.

Dental plaque-degrading compositions

This invention is a solid breath cleansing confection and a method for its manufacture which comprises an ingestibly acceptable alpha-amylase of between 1-8 SKB units of alpha-amylase which is in sufficient amount to degrade starch. The alpha-amylase may be from any source but in the currently preferred embodiment it is a fungal alpha-amylase. The confection may further comprise a solid comestible confectionary base containing flavoring and a sweetener which does not promote tooth decay. The sweeteners may be natural or artificial and in the currently preferred embodiment the sweetener is sorbitol. The confectionary base may be a gum or lozenge base and the flavoring may be natural or artificial flavoring, for example, mint flavoring such as natural or artificial wintergreen or natural or artificial spearmint.

Amylase containing breath cleansing confection

alpha amylase

dental caries

alpha amylase/dental caries

Alpha-amylase inhibitors: the montbretins and uses thereof

Dental plaque-degrading compositions

Amylase containing breath cleansing confection

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