Particular naturally occurring glycosylated acyl-flavonols are now shown to be effective mammalian .alpha.-amylase inhibitors. Such compounds can be obtained from plants of the genus Crocosmia and the compounds are useful in controlling starch digestion such as for management of glycemia in pre-diabetic or diabetic subjects, for management of obesity or for inhibiting oral caries or plaque formation.

Withers; Stephen

Tarling; Andrew C.

Andersen; Raymond

Brayer; Gary D.

Woods; Katherine

The University of British Columbia

Alpha-amylase inhibitors: the montbretins and uses thereof

Control of weight gain has long been a problem for many people who if they lose weight by dieting often gain it back in a short period of time. Therefore, there has been much research to find a simple means to control weight in humans.Acarbose, an oligosaccharide, is an oral alpha glucosidase inhibitor. The mechanism of action of acarbose results from a competitive inhibition of pancreatic amylase and membrane bound intestinal aplpha-glucoside hydrolase enzymes. Pancreatic alpha amylase hydrolizes complex starches in the lumen of the small intestine. The membrane bound intestinal alpha glucosidases hydrolyze oligo saccharides, trissaccharides and disaccharides to glucose and other monosaccharides in the brush boarder of the small intestines. It has no inhibitory effect against lactase and would therefore not be expected to induce the symptoms of lactose intolerance. The weight gain or loss for an individual is essentially the difference between the calories absorbed and the calories burned.

Use for drug acarbose precose for weight control prevention of weight gain for weight loss for treatment and prevention of obesity

Provided are methods, uses and pharmaceutical compositions for inhibition of mammalian alpha-amylase in a subject, with a Helianthamide peptide or a derivative thereof in a biologically effective amount. The subject in need of alpha-amylase inhibition, may have or be at risk of developing one or more of the following: Middleton syndrome; a motility disorder of the gastrointestinal tract; postprandial reactive hypoglycemia; postprandial syndrome; irritable bowel syndrome; diabetes mellitus type 1; diabetes mellitus type 2; pre-diabetes; obesity, dumping syndrome; infant dumping syndrome; polycystic ovary syndrome; steatohepatitis; and viral infection.

THE UNIVERSITY OF BRITISH COLUMBIA

Mammalian glucosidase inhibitors, methods for their use and pharmaceutical compositions thereof

alpha amylase

offita

obesity

alpha amylase/offita

Alpha-amylase inhibitors: the montbretins and uses thereof

Use for drug acarbose precose for weight control prevention of weight gain for weight loss for treatment and prevention of obesity

Mammalian glucosidase inhibitors, methods for their use and pharmaceutical compositions thereof

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