anticonvulsants/offita

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Bodyweight gain and anticonvulsants: a comparative review.

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Bodyweight gain is a common and frequent undesirable effect associated with the use of anticonvulsant drugs. This has been observed for many years with valproic acid (sodium valproate) and carbamazepine, and also, more recently, with some of the newer anticonvulsants such as vigabatrin and

Targets for medical therapy in obesity.

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Obesity has more than doubled since 1980 all over the world, and in the European perspective it does not seem to be better. Obesity-related diseases like diabetes, hypertension, coronary heart disease, stroke and hyperlipidemia are the main cause of mortality and morbidity in developed countries.

Three children with a syndrome of obesity and overgrowth, atypical psychosis, and seizures: a problem in neuropsychopharmacology.

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Three children presented with a complex syndrome of atypical psychotic and extremely immature behavior, obesity and overgrowth, borderline retardation, and seizures (prominent in two). Weight overgrowth exceeded height overgrowth and was stratospheric (up to 8 SD above mean). Obesity seemed related

Clinical evaluation of anti-obesity drugs.

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Obesity is a major health problem and as a result, it is reasonable to consider pharmacological approaches alongside approaches involving diet, physical activity and lifestyle change. The currently available drugs, sibutramine and orlistat, result in modest, clinically worthwhile weight loss, with

Obesity: new perspectives and pharmacotherapies.

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There is a widespread epidemic of obesity in the United States, which has been associated with an increased risk of diabetes mellitus, cancer, and cardiovascular diseases. Although lifestyle modifications and long-term dietary vigilance remain cornerstones of weight reduction treatment, the

Increased response of plasma allopregnanolone to corticotropin-releasing hormone in obese patients.

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Allopregnanolone is a neuroactive steroid present in the brain, but also measurable in systemic circulation. It exhibits anxiolytic and anticonvulsant effects and is able to produce hyperphagia. Since eating behavior disturbances and increased peripheral basal sympathetic activity have been reported

Topiramate induces weight loss and improves insulin sensitivity in dietary obese rats: comparison to sibutramine.

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OBJECTIVE Topiramate is newly approved as anticonvulsant that seems to promote body weight loss in humans. The present study was designed to evaluate the weight-controlling properties of topiramate in dietary obese female rats in comparison with sibutramine. METHODS Fifty rats were assigned as

The role of prescription medications in the association of self-reported sleep duration and obesity in U.S. adults, 2007-2012.

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Previous research has not investigated the role of prescription medication in sleep-obesity associations despite the fact that 56% of U.S. adults take at least one prescription medication. Data from n = 16,622 adults in the National Health and Nutrition Examination Survey (2007-2012) were used to

Obesity, polycystic ovarian syndrome and thyroid dysfunction in women with epilepsy.

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BACKGROUND Women with epilepsy (WWE) have an increased risk for several endocrine disorders. Obesity and Polycystic Ovarian Syndrome (PCOS) are common side-effects of anticonvulsant drugs. OBJECTIVE To study the prevalence of Obesity, PCOS, Thyroid dysfunction in WWE on monotherapy with

Evaluation of a rat model of valproate-induced obesity.

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Long-term treatment with the anticonvulsant valproate (VPA) leads to well-documented weight gain and obesity in humans. In an attempt to develop an animal model of this condition, adult rats were given VPA 20 g/kg (high-dose) or 2 g/kg (low-dose) in their daily feeding or orally 120 mg/kg body

Febrile convulsions, ataxia, developmental delay, and obesity: a new syndrome?

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We describe the association of recurrent complicated febrile convulsions, developmental delay, ataxia, and obesity in three unrelated girls. The three girls, aged 3 to 4 years, were all born to healthy, nonconsanguineous parents and have normal siblings. Their birth weight was appropriate for

Do obese depressed patients respond to topiramate? A retrospective chart review.

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BACKGROUND Topiramate, a novel anticonvulsant, has shown promise in preliminary open trials in bipolar disorder, but there are no studies in primary depression. Topiramate's tendency to cause weight loss could be advantageous for many patients with mood disorders. METHODS A chart review was

Add-on topiramate reduces weight in overweight patients with affective disorders: a clinical case series.

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BACKGROUND The weight-gain caused by many psychotropic drugs is a major cause for poor compliance with such medications and could also increase cardio-vascular morbidity among psychiatric patients. Recent reports have shown that the anticonvulsant topiramate causes weight loss in various patient

The effect of gabapentin on reducing pain after laparoscopic gastric bypass surgery in patients with morbid obesity: a randomized clinical trial.

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BACKGROUND Pain after laparoscopic gastric bypass surgery (LGBP) is a major problem. Gabapentin is an anticonvulsant drug that can be effective in postoperative pain control. OBJECTIVE This study examined the effect of preoperative administration of gabapentin on reducing pain after LGBP in patients

[Prevalence of psychoactive drug consumption in an obese population].

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OBJECTIVE To establish the prevalence of psychoactive drug consumption in an obese population. METHODS We collected data from the clinical records of obese patients attending the Endocrinology and Nutrition Department and Psychiatry Department of Hospital del Mar between June 2005 and May 2006

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