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Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase.

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The cell wall of Mycobacterium tuberculosis and related genera is unique among prokaryotes, consisting of a covalently bound complex of mycolic acids, D-arabinan and D-galactan, which is linked to peptidoglycan via a special linkage unit consisting of Rhap-(1-->3)-GlcNAc-P. Information concerning

Antigen 85C-mediated acyl-transfer between synthetic acyl donors and fragments of the arabinan.

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Antigen 85 (ag85) is a complex of acyltransferases (ag85A-C) known to play a role in the mycolation of the D-arabino-D-galactan (AG) component of the mycobacterial cell wall. In order to better understand the chemistry and substrate specificity of ag85, a trehalose monomycolate mimic p-nitrophenyl

Immunochemical analysis of tuberculin purified protein derivative with special reference to United States-Japan antigen 7.

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Immunochemical analysis of tuberculin purified protein derivative (PPD) by crossed immunoelectrophoresis and other agar gel techniques revealed substantial variation in antigen levels among PPDs and significant differences that were dependent upon the antiserum used. D-Arabino-D-mannan was

Suppression of lymphocyte responses by tuberculous plasma and mycobacterial arabinogalactan. Monocyte dependence and indomethacin reversibility.

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During tuberculosis, exposure of monocytes to circulating factors may induce the suppressor activity observed in some anergic patients. To explore this possibility, we examined the effects of plasma pooled from 28 untreated tuberculosis (TB) patients and the mycobacterial cell wall polysaccharide

Immunologic aspects of mycobacterial infections.

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Immunosuppressive mechanisms loom as important factors in depression of delayed-type hypersensitivity responses during active tuberculosis. Nonspecific suppression may be mediated by circulating immune complexes containing mycobacterial polysaccharides such as D-arabino-D-galactan. The mechanism of

Biosynthesis of the linkage region of the mycobacterial cell wall.

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The "core" structure of the cell wall of Mycobacterium and related genera is unique among prokaryotes, consisting of a covalently linked complex of mycolic acids, D-arabinan and D-galactan (mycolylarabinogalactan, mAG), which, in turn, is linked to peptidoglycan via a special linkage unit,

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Herbal & Natural Medicine

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