Adults balanced across the weight spectrum who have tried cannabis at least once with no negative reaction but are not regular users.

Sample of current cannabis users and non-users balanced across the weight spectrum who are matched on age, gender, BMI and physical activity.

Blood samples collected for insulin sensitivity, inflammation markers, and cannabinoid quantitation

Type 2 Diabetes

Obesity

Cannabis Use

Insulin Sensitivity

Center for Innovation and Creativity

Exploring the Anti-inflammatory Properties of Cannabis and Their Relevance to Insulin Sensitivity

Change in Circulating Levels of Cytokines (TNF-α, IL-1B, IL-4, IL-6, IL-10, IL-13, MCP-1)

Calculation of Insulin Sensitivity using changes in fasting plasma glucose (FPG) and fasting plasma insulin (FPI).
Measurements are collected on venous blood samples at 0, 30, 60, 90, and 120 minutes after ingestion of 75 grams oral glucose during oral glucose tolerance test (OGTT)
Matsuda Index is calculated as follows: 10000/sqrt ((FPG X FPI) X (Mean OGTT glucose concentration X Mean OGTT insulin concentration))

Change in glucose over time after ingestion of 75 grams oral glucose measured during during oral glucose tolerance test (OGTT). Measurements are collected on venous blood samples at 0, 30, 60, 90, and 120 minutes.

Change in insulin over time after ingestion of 75 grams oral glucose measured during OGTT. Measurements are collected on venous blood samples at 0, 30, 60, 90, and 120 minutes.

Interviewer administered assessment of number of minutes of mild, moderate, and vigorous physical activity over the previous seven days.

Pittsburgh Sleep Quality Index: Measurement of the quality and patterns of sleep from poor to good measuring seven domains (e.g., latency, duration, disturbances) over the last 2 weeks.

Frequency and quantity of cannabis use, age of first use, peer use, perceived risk from cannabis, and perceived availability of cannabis

Based on DSM V criteria that were converted to a self-report to assess dependence and other problems related to the use of cannabis

A 15-item scale used to collect information on withdrawal symptoms participants may be experiencing due to lack of use of marijuana

Standardized assessment of the extent of alcohol use and problems related to alcohol use

Calendar-based assessment of daily substance use for the 30 days prior to the baseline session only for both studies

The SF-12 Health Survey is a 12-item questionnaire used to assess general health and well-being and includes domains of physical functioning, role-physical, pain, general health, vitality, social functioning, role-emotional and mental health

Interviewer administered recall measure developed by the University of Minnesota Nutrition Coordinating Center (NCC), that facilitates the standardized collection of 24-hour dietary recall data

Self-report measure of a single item comprising six descriptive categories ranging from inactive to very active

Daily surveys sent to Study B participants during the four-week period between study visits querying for cannabis use, alcohol use, minutes of exercise, and consumption of fruits and vegetables

diabetes mellitus type 2/kannabis

Exploring the Anti-inflammatory Properties of Cannabis and Their Relevance to Insulin Sensitivity

Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum