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fibrosis/proline

Krækjan er vistuð á klemmuspjaldið
11 niðurstöður

Serine protease inhibitors-proline analogs

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The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin.

Substituted N-arylsulfonyl-proline derivatives as potent cell adhesion inhibitors

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SUMMARY OF THE INVENTION The compounds of the present invention are antagonists of the VLA-4 integrin ("very late antigen-4"; CD49d/CD29; or .alpha..sub.4.beta..sub.1), the .alpha..sub.4.beta..sub.7 integrin (LPAM-1 and .alpha..sub.4.beta..sub.p), and/or the .alpha..sub.9.beta..sub.1 integrin, and

Bile acid conjugates of proline hydroxylase inhibitors

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The oral administration of pharmaceuticals is the most common and most convenient type of pharmaceutical administration. However, in order for an active compound to pass into the bloodstream, an absorption process has to take place in the gastrointestinal tract. The pharmaceutical is then

Benzoquinone derivatives

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This invention relates to novel benzoquinone derivatives having inhibitory activities of protocollagen proline hydroxylase, collagen biosynthesis and 5-lipoxygenase. Protocollagen proline hydroxylase is an enzyme which specifically hydroxylates the proline residues of the protocollagen synthesized

Benzoquinone derivatives and production thereof

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This invention relates to novel benzoquinone derivatives having inhibitory activities of protocollagenproline hydroxylase, collagen biosynthesis and 5-lipoxygenase. Protocollagen proline hydroxylase is an enzyme which specifically hydroxylates the proline residues of the protocollagen synthesized by

Benzoquinone derivatives and production thereof

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This invention relates to novel benzoquinone derivatives having inhibitory activities of protocollagenproline hydroxylase, collagen biosynthesis and 5-lipoxygenase. Protocollagen proline hydroxylase is an enzyme which specifically hydroxylates the proline residues of the protocollagen synthesized by

Benzoquinone derivatives and production thereof

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Skráðu þig / skráðu þig
This invention relates to novel benzoquinone derivatives having inhibitory activities of protocollagen proline hydroxylase, collagen biosynthesis and 5-lipoxygenase. Protocollagen proline hydroxylase is an enzyme which specifically hydroxylates the proline residues of the protocollagen synthesized

Benzoquinone derivatives and production thereof

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This invention relates to novel benzoquinone derivatives having inhibitory activities of protocollagen-proline hydroxylase, collagen biosynthesis and 5-lipoxygenase. Protocollagen proline hydroxylase is an enzyme which specifically hydroxylates the proline residues of the protocollagen synthesized

Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use

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The present invention relates generally to the treatment of fibrotic conditions, and to the use of antifibrotic agents for the modification of such diseases. The fibrotic conditions addressed herein include changes in the structure and function of various organs in connection with the metabolism of

Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use

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The present invention relates generally to the treatment of fibrotic conditions, and to the use of antifibrotic agents for the modification of such diseases. The fibrotic conditions addressed herein include changes in the structure and function of various organs in connection with the metabolism of

Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use

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The present invention relates generally to the treatment of fibrotic conditions, and to the use of antifibrotic agents for the modification of such diseases. The fibrotic conditions addressed herein include changes in the structure and function of various organs in connection with the metabolism of
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