A pharmaceutical composition comprising a pharmaceutically effective amount of histamine-added immunoglobulin substantially suppresses edema formation and an increase of vascular permeability of the blood-brain barrier. The histamine-added immunoglobulin may be administered with a high degree of safety and a low incidence of side effects. The histamine-added immunoglobulin and pharmaceutical compositions containing it may be used for treatment and prevention of edema, edema formation, and an increase of vascular permeability of the blood-brain barrier.

Nippon Zoki Pharmaceutical Co., Ltd.

Anti-edema agent

The invention comprises a method for treatment of chronic and referred pain such as chronic headaches and migraine headaches, as well as pain of the upper back, neck and shoulders, and lower back pain using low power laser light. The source of such referred pain involves microscopic and macroscopic tears in the periosteal-osseous junctions of the upper vertebrae, the scapula, and the skull. These lesions stimulate the generation of histamines, kinins, bradykinins, prostaglandin, proteolytic enzymes, seratonin, and other substances which cause numerous localized autonomic reactions, such as muscle spasm, ischemia, local inflammation, edema, as well as generalized reactions such as increased blood pressure, photophobia, nausea, blurred vision, copious mucous flow of the nose and sinus, and the like. The muscle spasms are responsible for transmitting the pain sensation to other portions of the body, and the systemic reactions are often associated with migraine-type headaches. The sites of the periosteal-osseous lesions can be correlated directly with the distant locus of the referred pain sensation. The laser energy is directed to the sites of the lesions to cause an increase in lymphatic circulation at the site of the causative lesion in response to the laser energy. Laser energy delivered to the site results in increased blood circulation and cellular metabolism in the area, which promotes more rapid healing of the lesion.

DioLase Corporation

Method for pain relief using low power laser light

The present invention provides a method for preventing or treating an allergic disease, comprising administering to a subject a composition comprising an extract from Illicium verum as an active ingredient. The extract from Illicium verum of the present invention reduces the secretion amount of increased histamine by compound 48/80 and the production amount of the increased allergenic cytokines (TNF-.alpha., IL-4 and IL-8) by PMA and A23187. The Illicium verum extract of the present invention reduces edema, dermatitis and IgE concentration of serum in atopic dermatitis mouse model. The Illicium verum extract of the present invention may be efficiently use for prevention, improvement or treatment of various allergic disease such as edema, hypersensitivity, contact dermatitis, atopic dermatitis, skin allergy, asthma or urticaria as pharmaceutical compositions, skin external applications, cosmetic compositions or food compositions.

Yoon; TaeSook

Sung; Yoon-Young

Yang; Won-Kyung

Kim; Ho Kyoung

Korea Institute of Oriental Medicine

Method for preventing or treating an allergic disease using extract from illicium verum

An azaazulene derivative having the general formula (I): ##STR1## wherein R.sup.1 is hydrogen atom or isopropyl group; the bond C N between C at the 2-position and N at the 1-position is single bond or double bond; when the bond C N is single bond, R.sup.2 is 5-tetrazolyl group, R.sup.3 is taken together with carbon atom to form carbonyl group at the 2-position, and R.sup.4 is hydrogen atom, an alkyl group having 1 to 18 carbon atoms, a lower alkenyl group, a lower alkyl group having oxygen atom or sulfur atom in carbon chain, a lower alkyl group having a halogen atom or cyano group, a lower alkyl group having heteroaromatic ring, a diphenyl lower alkyl group, or a lower alkyl group having hydrocarbon-aromatic ring with the general formula: ##STR2## in which W is single bond or carbonyl group, oxygen atom, sulfur atom or --CH.dbd.CH--, n is an integer of 1 to 6, and R.sup.1', R.sup.2' and R.sup.3' are the same or different and each is hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxyl group, trifluoromethyl group, hydroxyl group, a lower alkoxycarbonyl group, carboxyl group, acetyl group or cyano group; when the bond C N is double bond, N at the 1-position has no substituent R.sup.4, R.sup.2 is cyano group, and R.sup.3 is amino group or a salt thereof, azido group, a diphenyl lower alkyl amino group, a substituted phenyl amino group, a substituted piperazinyl group, a substituted homopiperazinyl group, an amino acid residue bonded by N terminal group in which C terminal group is carboxyl group or a lower alkyl ester thereof, or a lower alkyl amino group which may have an alkyl amino group that may be cyclic one, or a salt thereof, which is useful as an active ingredient of an antiallergic agent and an antiinflammatory agent and has also an inhibitory activity against histamine release, 5-lipoxygenase inhibiting activity, relaxing activity of smooth musculus trachealis and inhibitory activity against carrageenin edema, and further, is useful as medicine for prevention and treatment of bronchial asthma, allergic coryza, allergic conjunctivitis, urticaria, atopic dermatitis, other inflammatory diseases or the like.

histamine/bjúgur

Anti-edema agent

Method for pain relief using low power laser light

Method for preventing or treating an allergic disease using extract from illicium verum

Azaazulene compounds which are useful as antiallergic and antiinflammatory agents

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