Anesthesia

Opioid-Related Disorders

Dexmedetomidine

Remifentanil

Clermont-Ferrand University Hospital

Beaujon Hospital

Lille University Hospital

Metz-Thionville Hospital

Montpellier University Hospital

Nantes University Hospital

Nimes University Hospital

Perigueux Hospital

Rennes University Hospital

Saint-Brieuc Hospital

Toulouse University Hospital

Postoperative and Opioid Free Anesthesia

Effect of Opioid-free Anesthesia on Postoperative Opioid-related Adverse Events After Major or Intermediate Non-cardiac Surgery: a Multicenter Prospective Randomized Controlled Study

Postoperative hypoxemia is defined as an oxygen saturation (SpO2) < 95% with a need for oxygen supplementation within the first 48h after extubation; the duration of oxygen treatment will also be recorded.
Postoperative ileus is defined as an absence of flatus or stools within the first 48h after extubation.
Postoperative cognitive dysfunction will be evaluated using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) by a care provider (either anesthesiologist or nurse).

Bradycardia is defined as the number of episodes with atropine administration. Hypotension is defined as mean arterial blood pressure < 65 mmHg. Hypertension is defined as mean arterial blood pressure > 90 mmHg.

Ibuprofen has been shown to prevent AMS from previous studies.

Acetaminophen has not been tested yet in AMS prevention.

Acute Mountain Sickness, Blood Oxygen Saturation, Headache

Ibuprofen

Acetaminophen

Buddha Basnyat, MD

Ibuprofen vs Acetaminophen for AMS Prevention

Ibuprofen vs Acetaminophen in the Prevention of Acute Mountain Sickness: A Double Blind, Randomized Controlled Trial

AMS diagnosis will be done using Lake Louise Questionnaire (LLQ) which requires a score of three or greater with the mandatory presence of headache and at least one of the following symptoms: dizziness or light-headedness, fatigue, gastrointestinal (GI) symptoms (nausea/vomiting), or difficulty sleeping.
LLQ is a self-report symptom questionnaire and it will be assessed among all the study participants upon arrival to the study end point i.e. 5000m altitude (Lobuche) as specified above.

Blood oxygen saturation (percentage of oxygen in the blood) among all the study participants will be measured using Pulse Oximetry. The percentage of oxygen in the blood measured will be abbreviated as SPO2 in the spreadsheet.

Heart rate (HR) will be assessed among all the study participants using Pulse Oximetry. The heart rate measured in the study will be abbreviated as HR in the spreadsheet.

High altitude headache (HAH) and its severity will be scored based on a Visual Analog Scale (VAS) and the headache score identified on the designated LLQ score upon arrival to the study end point i.e. 5000m altitude (Lobuche).

Buddha Basnyat

Mountain Medicine Society of Nepal

induced sputum cells and peripheral blood sample

Asthma

UZ Leuven

Guidance of Patients With Asthma During Preparation and During Expedition to the Aconcagua Mountain

Sputum cells and cytokine messenger ribonucleic acid will be analyzed to determine the type of airway inflammation that is induced by several triggers (exercise, hypoxia and cold air)

Mean Lake Louise Score in subjects
Number of subjects with Lake Louise Score > 5
Mean change in daily asthma symptom score
Mean change in Asthma control test score
Number of participants with an acute asthma exacerbation

Dr. Lieven Dupont

Prof. dr.

Universitaire Ziekenhuizen Leuven

addition of 4% oxygen to the carbon dioxide pneumoperitoneum

Pain

Inflammation

addition of 4% oxygen

classic pneumoperitoneum with 100 % carbon dioxide

histamine/hypoxia

Postoperative and Opioid Free Anesthesia

Ibuprofen vs Acetaminophen for AMS Prevention

Guidance of Patients With Asthma During Preparation and During Expedition to the Aconcagua Mountain

Evaluation of Adding Small Amounts of Oxygen to the CO2 Pneumoperitoneum Upon Pain and Inflammation

Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum