hypothermia/hypoxia

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Molecular characterization of hypoxia-hypothermia-conditioned human endothelial cells and their interaction with human monocytes.

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This in vitro study was designed to characterize the molecular profiling of human endothelial cells (ECs) during the early phase of hypoxia-hypothermia (HH) conditioning and to evaluate their interactions with allogeneic monocytes. The HH-conditioned ECs were analyzed using real-time quantitative

Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation.

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Hypothermia therapy has a positive effect on patients with severe brain injury. Recent studies have shown that mild hypothermia increases the survival of bone marrow-derived mesenchymal stem cells (BMSCs) in a hypoxic environment; however, the underlying mechanisms are not yet fully understood.

[Function of the respiratory system in miners with chronic regional hypobaric hypoxia and hypothermia].

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The role of meteotropic factors (low atmospheric pressure and cold climate) in the development of functional disorders of respiratory system was studied for miners of the North-East region of the USSR. Regularities in forming external respiration dysfunctions during adaptation of migrating

[Characteristics of conjugate functions of the vessels of skeletal muscles and intestines during separate and combined action of hypoxia and hypothermia on the body].

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In regimen of the constant blood flow perfusion of skeletal muscles and intestine, hypoxia reduced precapillary resistance and increased the capillary filtration coefficient in both organs whereas postcapillary resistance and capillary pressure were reduced in the intestine and increased in the

Protein synthesis is defended in the mitochondrial fraction of gill but not heart in cunner (Tautogolabrus adspersus) exposed to acute hypoxia and hypothermia.

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The cunner, Tautogolabrus adspersus, is a north-temperate teleost which relies upon metabolic depression to survive the extreme low water temperatures of its habitat during the winter. Previous study has demonstrated a decrease in protein synthesis accompanies the metabolic depression observed at

Hypoxia and hypothermia enhance spatial heterogeneities of repolarization in guinea pig hearts: analysis of spatial autocorrelation of optically recorded action potential durations.

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BACKGROUND Regional dispersions of repolarization (DOR) are arrhythmogenic perturbations that are closely associated with reentry. However, the characteristics of DOR have not been well defined or adequately analyzed because previous algorithms did not take into account spatial heterogeneities of

Ventilation- and carotid chemoreceptor discharge-response to hypoxia during induced hypothermia in halothane anesthetized rat.

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It has been hypothesized that respiratory "gain" to hypoxic stimulus is not depressed in hypothermic animals though ventilation and that metabolic O(2) demand (Vo(2)) decreases with reduction in body temperature. The present study addressed this hypothesis by quantitative analysis of ventilatory and

Neuroprotective effect of hypothermia on neuronal injury in diffuse traumatic brain injury coupled with hypoxia and hypotension.

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It is well established in mechanical head trauma that posttraumatic secondary insults, such as hypoxia and hypotension exacerbate neuronal injury and lead to worse outcome. In this study, the neuroprotective effect of hypothermia on the reduction of supraventricular subcortical neuronal damage was

Moderate hypothermia induces protection against hypoxia/reoxygenation injury by enhancing SUMOylation in cardiomyocytes

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Moderate hypothermia plays a major role in myocardial cell death as a result of hypoxia/reoxygenation (H/R) injury. However, few studies have investigated the molecular mechanisms of hypothermic cardioprotection. Several responses to stress and other cell functions are regulated by

Effects of hypothermosol, an experimental acellular solution for tissue preservation and cardiopulmonary bypass, on isolated newborn lamb coronary vessels subjected to ultra profound hypothermia and anoxia.

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Ultra profound hypothermia (4 to 10 degrees C) is an experimental method aiming at safely prolonging organ and total body preservation. For this purpose, Hypothermosol (HTS), an investigational acellular solution for blood substitution, was demonstrated to be beneficial in animal models undergoing

Arrhythmogenesis in the developing heart during anoxia-reoxygenation and hypothermia-rewarming: an in vitro model.

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BACKGROUND The spatio-temporal pattern of arrhythmias in the embryonic/fetal heart subjected to a transient hypoxic or hypothermic stress remains to be established. RESULTS Spontaneously beating hearts or isolated atria, ventricles, and conotruncus from 4-day-old chick embryos were subjected in

Activation of AMP-dependent protein kinase by hypoxia and hypothermia in the liver of frog Rana perezi.

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We have investigated different signaling molecules that could be activated by temperature acclimation and hypoxia, using an experimental approach consisting in submerging frogs in a water-filled box maintained at 2-4 degrees C at ambient oxygen levels or supplied with 98% N2:2% CO2 for normoxia or

Regional effects of hypoxia and hypothermia on rebound excitation in large intestine of piebald mouse model for Hirschsprung's disease.

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Effects of hypoxia and hypothermia on the poststimulus rebound contractile response (PSRR) were studied in the circular muscle coat of the large intestine of the piebald mouse model for Hirschsprung's disease. The PSRR in the terminal segment of the normal large intestine, which corresponds to the

[The organic macro- and microhemodynamics and the systemic circulation under the combined action of hypoxia and hypothermia].

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In regimen of the constant blood flow perfusion of shank and small intestine of cat combined effect of hypoxia (10% O2 in N2) and hypothermia (about 30 degrees C) involved a decrease in precapillary resistance, an increase in capillary filtration coefficient in both vascular regions, an increase in

Balancing hypoxia and hypothermia in cold-submerged frogs.

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Many animals respond to hypoxic stress by selecting cooler environments, the so-called 'behavioural hypothermia' response. Amphibians overwintering in ice-covered ponds and lakes offer an ecologically relevant test of this response since they must choose between the confounding metabolic effects of

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