hypoxia/fatigue

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Changes of intracellular milieu with fatigue or hypoxia depress contraction of skinned rabbit skeletal and cardiac muscle.

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1. Maximal calcium-activated force (Fmax) and calcium sensitivity were markedly decreased in detergent-skinned fibres from skeletal and cardiac muscle by solutions that mimicked the total milieu changes associated with fatigue and hypoxia. Further experiments determined the relative contribution of

Muscle Na-K-pump and fatigue responses to progressive exercise in normoxia and hypoxia.

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To investigate the effects of hypoxia and incremental exercise on muscle contractility, membrane excitability, and maximal Na(+)-K(+)-ATPase activity, 10 untrained volunteers (age = 20 +/- 0.37 yr and weight = 80.0 +/- 3.54 kg; +/- SE) performed progressive cycle exercise to fatigue on two

[Effects of the Fomes officinalis Ames. polysaccharides on anti-fatigue and hypoxia tolerance in mice].

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To study the effects of Fomes officinalis Ames. polysaccharides(FOPS) on anti-fatigue and hypoxia tolerance in mice.Forty-eight mice were randomly divided into control group, low-dose, middle-dose and high-dose group of FOPS (100, 200, 400 mg/kg). All mice

Impact of hypobaric hypoxia in pressurized cabins of simulated long-distance flights on the 24 h patterns of biological variables, fatigue, and clinical status.

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Long-distance flights can cause a number of clinical problems in both passengers and crewmembers. Jet lag as well as mild hypoxia resulting from incomplete cabin pressurization could contribute to these problems. The objective of this study was to assess, using a chronobiological approach, the

[The study of genistein attenuating genioglossus muscle fatigue under chronic intermittent hypoxia].

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OBJECTIVE To investigate the effects of genistein on genioglossus muscle function and nuclear factor erythroid 2 related factor 2(Nrf-2)/antioxidant responsive element(ARE) signaling pathway in rats under chronic intermittent hypoxia(CIH) condition in order to find medication treatment of

[Effect of high-oxygen water on enhancing anoxia endurance and anti-fatigue function and the possible mechanism].

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OBJECTIVE To investigate the effect of high-oxygen water on anoxia endurance and anti-fatigue function in mice and explore the possible mechanism. METHODS KM mice were used. Their body weight, serum urea nitrogen, hepatic glycogen, swimming-sustaining time of mice with a load, plasma lactic acid

Assessment of fatigue-related biochemical alterations in a rat swimming model under hypoxia.

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It is well known that exercise-induced fatigue is exacerbated following hypoxia exposure and may arise from central and/or peripheral mechanisms. To assess the relative contribution of peripheral and central factors to exercise-induced fatigue under hypoxia, a rat model of fatigue by a bout of

Effects of caffeine on neuromuscular fatigue and performance during high-intensity cycling exercise in moderate hypoxia.

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OBJECTIVE To investigate the effects of caffeine on performance, neuromuscular fatigue and perception of effort during high-intensity cycling exercise in moderate hypoxia. METHODS Seven adult male participants firstly underwent an incremental exercise test on a cycle ergometer in conditions of acute

Mechanism and effects of fructose diphosphate on anti-hypoxia fatigue and learning memory ability

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This study aims to investigate the mechanisms through which Fructose Diphosphate (FDP) causes the anti-hypoxia and anti-fatigue effects, and improves learning and memory. Mice were divided into three groups: FDP-L，FDP-H and a control group. Acute toxic hypoxia induced by carbon monoxide, sodium

Effect of carbohydrate ingestion on central fatigue during prolonged running exercise in moderate hypoxia.

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To determine if acute exposure to moderate hypoxia alters central and peripheral fatigue, and to test whether carbohydrate ingestion impacts fatigue characteristics, 12 trained runners completed 3 running trials lasting 1 h each at 65% of normoxic V̇O2max. The first trial was performed in normoxia

Genistein attenuates genioglossus muscle fatigue under chronic intermittent hypoxia by down-regulation of oxidative stress level and up-regulation of antioxidant enzyme activity through ERK1/2 signaling pathway.

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OBJECTIVE This study aims to investigate the effects of genistein on contractile properties of genioglossus under chronic intermittent hypoxia (CIH) conditions and its relationship with oxidative stress, antioxidant enzyme, and ERK1/2 signaling pathway. METHODS Fifty female Sprague-Dawley rats were

The anti-fatigue and anti-anoxia effects of Tremella extract.

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The present study intended to explore the anti-fatigue and anti-hypoxia efficacy of Tremella extract in mouse model.Kunming mice were randomized into 5 groups randomly (n = 12/group; half male and female), and given 0.9%Nacl (10 mL/Kg Serving as blank

Liver CEBPβ Modulates the Kynurenine Metabolism and Mediates the Motility for Hypoxia-Induced Central Fatigue in Mice.

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Central fatigue is defined as a failure of the central nervous system to adequately drive the muscle, manifesting limited development, and maintenance of locomotor activity. A plateau in hypoxia leads to central fatigue and followed by maximal motility recession. However, the underlying mechanism is

L-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats.

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The concept of L-carnitine (L-CAR) supplementation to improve muscular performance is based on the role of L-CAR in regulating aerobic metabolism. L-CAR has also been found to attenuate free radical-induced oxidative stress in various pathological conditions. Thus, it was hypothesized that L-CAR may

Reactive oxygen species mediated diaphragm fatigue in a rat model of chronic intermittent hypoxia.

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Respiratory muscle dysfunction documented in sleep apnoea patients is perhaps due to oxidative stress secondary to chronic intermittent hypoxia (CIH). We sought to explore the effects of different CIH protocols on respiratory muscle form and function in a rodent model. Adult male Wistar rats were

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