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hypoxia/infarction

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Bls 1 frá 34 niðurstöður

Periostin induces proliferation of cardiomyocytes and promotes cardiac regeneration

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BACKGROUND OF THE INVENTION Cardiovascular diseases are a leading cause of death resulting in almost 40% of deaths annually in the United States. Inadequate human myocardial regeneration poses a significant public health problem. It is estimated that 13 million Americans have coronary artery

MAPC treatment of brain injuries and diseases

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FIELD OF THE INVENTION The field of the invention is treatment of brain injury, disorder, dysfunction, and disease using multipotent adult progenitor cells ("MAPCs"), in particular the treatment of hypoxic and ischemic brain injuries, including but not limited to Hypoxic-Ischemic Brain Injury and

Methods of intravenous administration of glyburide

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FIELD OF THE INVENTION This invention relates to the field of medical treatment methods, including intravenous methods of administration of drugs to a subject. BACKGROUND Glyburide (also known as, e.g., glibenclamide) is a sulfonylurea drug used in treating diabetes. The systematic name of glyburide

Methods of intravenous administration of glyburide

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FIELD OF THE INVENTION This invention relates to the field of medical treatment methods, including intravenous methods of administration of drugs to a subject. BACKGROUND Glyburide (also known as, e.g., glibenclamide) is a sulfonylurea drug used in treating diabetes. The systematic name of glyburide

Methods of intravenous administration of glyburide

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FIELD OF THE INVENTION This invention relates to the field of medical treatment methods, including intravenous methods of administration of drugs to a subject. BACKGROUND Glyburide (also known as, e.g., glibenclamide) is a sulfonylurea drug used in treating diabetes. The systematic name of glyburide

Prodrug salts

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TECHNICAL FIELD Provided are novel prodrug salts of selective aquaporin inhibitors, e.g., of aquaporin-4 and/or aquaporin-2, of Formula I as described below, their use as pharmaceuticals and pharmaceutical compositions comprising them, and novel intermediates used in and novel processes for their

Prodrug salts

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TECHNICAL FIELD Provided are novel prodrug salts of selective aquaporin inhibitors, e.g., of aquaporin-4 and/or aquaporin-2, of Formula I as described below, their use as pharmaceuticals and pharmaceutical compositions comprising them, and novel intermediates used in and novel processes for their

Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose

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BACKGROUND OF THE INVENTION The present invention relates to a health food/dietary supplement comprising as its characterising ingredients an alkanoyl L-carnitine selected from the group consisting of isovaleryl L-carnitine and propionyl L-carnitine or their pharmacologically acceptable salts or

Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose

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BACKGROUND OF THE INVENTION The present invention relates to a health food/dietary supplement comprising as its characterising ingredients an alkanoyl L-carnitine selected from the group consisting of isovaleryl L-carnitine and propionyl L-carnitine or their pharmacologically acceptable salts or

Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists

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BACKGROUND OF THE INVENTION This invention is for novel glutamate receptor antagonists which are new compounds of the 5,6,7,8-substituted quinoxaline 2,3-dione type. The fused ring system is substituted at the a- or b-position by amino acid derivatives. The compounds are active as excitatory amino

Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists

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BACKGROUND OF THE INVENTION This invention is for novel glutamate receptor antagonists which are new compounds of the 5,6,7,8-substituted quinoxaline 2,3-diones type. The fused ring system is substituted at the a- or b-position by amino acid derivatives. The compounds are active as excitatory amino

Substituted quinoxaline-2-ones as glutamate receptor antagonists

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BACKGROUND OF THE INVENTION This invention is for novel glutamate receptor antagonists which are new compounds of the substituted quinoxaline 2-ones type. The compounds are active as excitatory amino acid receptor antagonists acting at glutamate receptors, including either or both

Sulfonamide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists

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BACKGROUND OF THE INVENTION The present invention concerns novel sulfonamide derivatives of substituted quinoxaline 2,3-diones having utility as glutamate receptor antagonists. The fused ring quinoxaline 2,3-dione system is substituted at the a- or b-position by sulfonamide derivatives. The

Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists

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BACKGROUND OF THE INVENTION This invention is for novel glutamate receptor antagonists which are new compounds of the 5,6,7,8-substituted quinoxaline 2,3-diones type. The fused ring system is substituted at the a or b position by amino acid derivatives. The compounds are active as excitatory amino

Protein S protects the nervous system from injury

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BACKGROUND OF THE INVENTION This invention relates to the use of protein S and/or variants thereof as neuroprotective agents for treating brain disorders and other pathological conditions. The ability of protein S and variants thereof to act as cell survival factors on cells of the nervous systems
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