morin/dental caries

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The role of sodium alginate and gellan gum in the design of new drug delivery systems intended for antibiofilm activity of morin

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The use of controlled drug delivery systems represents an alternative and promising strategy for the use of antimicrobials in the oral cavity. Microparticles, films and oral tablets based on alginate and gellan gum were developed also as a strategy to overcome the low aqueous solubility of morin.

Morin inhibits sortase A and subsequent biofilm formation in Streptococcus mutans.

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Streptococcus mutans (S. mutans) is the main etiological agent of dental caries, and adheres to the tooth surface through the sortase A (SrtA)-mediated cell wall-anchored protein Pac. Inhibition of SrtA activity results in a marked reduction in the adhesion potential of S. mutans, and the frequency

Voltammetric and spectroscopic studies on binding of antitumor Morin, Morin-Cu complex and Morin-beta-cyclodextrin with DNA.

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A systematic comparative study of the binding of antitumor Morin and its complexes with DNA has been investigated in the Britton-Robison (BR) buffer solutions using voltammetric and spectroscopic methods. The results show that Morin molecule, acting as an intercalator, is inserted into the cavity of

Molecular docking, synthesis, kinetics study, structure-activity relationship and ADMET analysis of morin analogous as Helicobacter pylori urease inhibitors.

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Urease are responsible for several pathogenic states in human as well as in animals and its inhibition is utmost urgent. Clinically used drugs are associated with many side effects; recently several researches have shown that flavonoids have good urease inhibition properties. Morin, a

Catalytic Behavior of Different Sizes of Dendrimer-Encapsulated Au(n) Nanoparticles in the Oxidative Degradation of Morin with H2O2.

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Different sizes of icosahedral-like dendrimer-encapsulated Au nanoparticles (Au55- and Au147-DENs) were prepared in the presence of generation 6 amine-terminated dendrimers (G6-PAMAM-NH2) as a template. The synthesis is carried out by the complexation of a Au metal precursor (AuHCI4) with the

Synthesis, topoisomerase I inhibitory and cytotoxic activities of chromone derivatives.

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A series of chromone derivatives were designed as potential topoisomerase I (Top I) inhibitors based on the docking simulation study. Sixteen synthesized compounds were evaluated for Top I inhibitory activity and some compounds were further tested for in vitro cytotoxic activity. The most potent

Flutelike porous hematite nanorods and branched nanostructures: synthesis, characterisation and application for gas-sensing.

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Flute-like porous alpha-Fe2O3 nanorods and branched nanostructures such as pentapods and hexapods were prepared through dehydration and recrystallisation of hydrothermally synthesised beta-FeOOH precursor. Transmission electron microscopy (TEM), high-resolution TEM and selected area electron

Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study.

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The pregnane X receptor (PXR) plays a critical role in the regulation of human cytochrome P450 3A4 (CYP3A4) gene. In this study, we investigated the effect of an array of compounds isolated from Chinese herbal medicines on the activity of PXR using a luciferase reporter gene assay in transiently

Effect of flavonoids on antimicrobial activity of microorganisms present in dental plaque.

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Dental caries is a multi-factorial oral disease, requiring a susceptible host, cariogenic microorganisms and suitable substrate. Caries is extended worldwide in spite of the availability of countless prophylactic means, including fluoride toothpaste and dental sealers. Many efforts

Novel insights into the inhibitory mechanism of kaempferol on xanthine oxidase.

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Xanthine oxidase (XO), a key enzyme in purine catabolism, is widely distributed in human tissues. It can catalyze xanthine to generate uric acid and cause hyperuricemia and gout. Inhibition kinetics assay showed that kaempferol inhibited XO activity reversibly in a competitive manner. Strong

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