ototoxicity/offita

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Therapeutic initiatives for the avoidance of aminoglycoside toxicity.

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Aminoglycosides continue to be indispensable in the management of serious and life-threatening aerobic gram-negative infections. On an annual basis in the United States, they are used in the management of four million patients. Despite their clinical utility, they continue to manifest a high profile

Reappraisal of guidelines for pharmacokinetic monitoring of aminoglycosides.

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The rationale for pharmacokinetic monitoring of aminoglycosides is critically reviewed. Retrospective studies suggest that for optimal antibacterial effect, peak serum gentamicin concentrations should exceed 5 micrograms/ml, despite the fact that these concentrations are indirect measures of the

Role of genetic susceptibility in development of treatment-related adverse outcomes in cancer survivors.

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Clear and unambiguous associations have been established between therapeutic exposures and specific complications. However, considerable interindividual variability is observed in the risk of developing an outcome for a given therapeutic exposure. Genetic predisposition and especially its

Evaluation of long-term toxicity after chemotherapy for testicular cancer.

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OBJECTIVE The current study evaluates the extent and reversibility of late sequelae after chemotherapy in longterm survivors of testicular cancer. The influence of therapy and patient characteristics and the relationship between different toxicities are assessed. METHODS Ninety patients with a

Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage.

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Hearing loss is the most common sensory disorder in humans, and a significant number of cases is due to the ototoxicity of drugs such as cisplatin that cause hair cell (HC) damage. Thus, there is great interest in finding agents and mechanisms that protect HCs from ototoxic drug damage. It has been

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Herbal & Natural Medicine

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