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Inhibition of poly(ADP-ribose) synthetase improves vascular contractile responses following trauma-hemorrhage and resuscitation.

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Hyporeactivity of vessels to constrictor agents is thought to contribute to cardiovascular decompensation following trauma-hemorrhage and resuscitation. In this study, we determined if inhibition of poly(ADP-ribose) synthetase (PARS) activity prevented the development of vascular hyporeactivity in

Activation of poly(ADP-ribose) polymerase in severe hemorrhagic shock and resuscitation.

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This study examines activation of poly(ADP-ribose) polymerase (PARP) in the ileum during hemorrhage and resuscitation and determines if inhibition of PARP reduces organ dysfunction and metabolic acidosis. Awake, nonheparinized rats were hemorrhaged (40 mmHg, 60 min). Resuscitation used Ringer's

Risk analysis of pancreatic fistula after pancreatic head resection.

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OBJECTIVE To evaluate the risk factors for pancreatic fistula after pancreatic head resection. METHODS Retrospective review. METHODS University hospital, in the 71-month period from January 1992 through November 1997. METHODS Sixty-two patients who underwent pancreatic head resection with

Synthesis and in Vitro and in Vivo Anticoagulant and Antiplatelet Activities of Amidino- and Non-Amidinobenzamides.

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Three amidino- and ten non-amidinobenzamides were synthesized as 3-aminobenzoic acid scaffold-based anticoagulant and antiplatelet compounds. The anticoagulant activities of thirteen synthesized compounds 1-13, and 2b and 3b as prodrugs were preliminary evaluated by screening the prolongation of

Purification and biochemical characterization of a fibrin(ogen)olytic metalloprotease from Macrovipera mauritanica snake venom which induces vascular permeability.

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In the present study, a novel fibrin(ogen)olytic metalloprotease from Macrovipera mauritanica snake venom was purified and characterized in terms of enzyme kinetics and substrate specificity. The purified enzyme [termed snake venom metalloprotease-Macrovipera mauritanica (SVMP‑MM)] was composed of a

[Value of various therapeutic procedures in penile induration].

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Etiology, pathogenesis and optimal therapy of Peyronie's disease are, 240 years after its first description, still unclear. Diagnosis includes palpation, measurement and exact drawing of the mostly dorsally and laterally located penile induration, photography of erectile deviation, cavernosography

Which is less invasive--distal pancreatectomy or segmental resection?

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BACKGROUND For a pancreatic body tumor, distal pancreatectomy (DP) has been a standard operation. Segmental resection (SR) of the pancreas has been introduced as a less invasive procedure in consideration of preservation of the pancreatic functions and postoperative quality of life. Surgical stress

Is there any benefit of preservation of the spleen in distal pancreatectomy?

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For a pancreatic body or tail tumor, distal pancreatectomy with splenectomy (DPS) is a standard operation. Spleen-preserving distal pancreatectomy (SPDP) was introduced in order to preserve the organ and thus provide the patient with a better quality of life. Clinical data were compared between 38

Which is a less invasive pancreatic head resection: PD, PPPD, or DPPHR?

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Less invasive pancreatic head resection, such as pylorus preserving pancreatoduodenectomy (PPPD) and duodenum preserving pancreatic head resection (DPPHR) has been introduced for the treatment of pancreatoduodenal lesions, especially for benign conditions, in consideration of postoperative quality

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Herbal & Natural Medicine

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