A peroxidase-activating oral care composition, in accordance with an embodiment of the invention, includes a non-enzymatic, water-soluble hydrogen peroxide precursor and a pH-adjusting agent capable of producing a selected pH in an aqueous solution. The composition facilitates the rapid release of hydrogen peroxide and results in the activation of a peroxidase enzyme in an oral cavity. A process for manufacturing the oral care composition including obtaining the precursor, dispersing it in a non-hygroscopic material so as to coat or encapsulate it, obtaining and associating the coated or encapsulated particles with a pH-adjusting agent, and formulating the particles into an oral care composition is provided in another embodiment. In addition, a method for activating a peroxidase system in an oral cavity of an animal, including selecting a non-enzymatic water soluble hydrogen peroxide precursor, mixing the precursor with a pH-adjusting agent, and administering the precursor and pH-adjusting agent in a suitable formulation to the oral cavity, is provided in a further embodiment of the invention.

Oraceutical Innovative Properties, LLC

Peroxidase-activating oral compositions

A peroxidase-activating oral care composition, in accordance with an embodiment of the invention, includes a non-enzymatic, water-soluble hydrogen peroxide precursor and a pH-adjusting agent capable of producing a selected pH in an aqueous solution. The composition facilitates the rapid release of hydrogen peroxide and results in the activation of a peroxidase enzyme in an oral cavity A process for manufacturing the oral care composition including obtaining the precursor, dispersing it in a non-hygroscopic material so as to coat or encapsulate it, obtaining and associating the coated or encapsulated particles with a pH-adjusting agent, and formulating the particles into an oral care composition is provided in another embodiment. In addition, a method for activating a peroxidase system in an oral cavity of an animal, including selecting a non-enzymatic water soluble hydrogen peroxide precursor, mixing the precursor with a pH-adjusting agent, and administering the precursor and pH-adjusting agent in a suitable formulation to the oral cavity, is provided in a further embodiment of the invention.

The bactericidal method of the invention comprises forming a bactericide having a limited period of bacteriological activity with the bactericide including; a peroxide, a peroxidase and a source of donor molecules adapted to act as a substrate for said peroxidase; activating the bactericide to cause a catalyzed reaction by said peroxidase for generating free radicals from said source of donor molecules and simultaneously applying the bactericide for killing bacteria in the treatment of dental disease in situ such as in the oral cavity or as a denture cleaner.

peroxidase/dental caries

Peroxidase-activating oral compositions

Peroxidase-activating oral compositions

Bactericidal method

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