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BACKGROUND OF THE INVENTION
Tumor necrosis factor alpha (TNF-.alpha.), also known as cachectin, is a 17 kDa protein produced by neutrophils, activated lymphocytes, macrophages, NK cells, LAK cells, astrocytes, endothelial cells, smooth muscle cells, and some transformed cells. A large number of
FIELD OF THE INVENTION
This invention relates to novel purine derivatives and pharmaceutical compositions containing thereof. The pharmaceutical compositions containing novel purine derivatives of the present invention are useful as suppressants for inflammatory diseases (anti-inflammatory drugs),
The present invention relates to substituted 9H-8-oxo-pyrimido[2,1-f]purine-2,4-diones and tautomers thereof. These compounds are useful as anti-inflammatory agents for treating inflammatory conditions such as arthritis, spondylitis, and tendonitis in mammals.
In a composition of matter aspect, the
BACKGROUND OF INVENTION
The present invention relates to substituted 2,3-dihydro-6-(hydroxy)pyrimido[2,1-f]purine-4,8(1H, 9H)-diones and tautomers thereof. These compounds are useful as anti-inflammatory agents for treating inflammatory conditions such as arthritis, spondylitis, and tendonitis in
BACKGROUND OF THE INVENTION
Tumor necrosis factor alpha (TNF-.alpha.), also known as cachectin, is a 17 kDa protein produced by neutrophils, activated lymphocytes, macrophages, NK cells, LAK cells, astrocytes, endothelial cells, smooth muscle cells, and some transformed cells. A large number of
The present invention relates to therapeutically active 2,6-diaminopurine-.beta.-D-ribofuranuronamide derivatives, processes for the manufacture of said compounds, pharmaceutical formulations containing said compounds and the use of said compounds in chemotherapy. In particular, we have found a
FIELD OF THE INVENTION
The present invention relates to novel purine derivatives or pharmaceutically acceptable salts thereof and their application as medicines. The medicine comprising a purine derivative or a pharmaceutically acceptable salt thereof of the present invention as an active ingredient
1. FIELD OF THE INVENTION
The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological
BACKGROUND OF THE INVENTION
This invention relates to purine derivatives, to processes for their preparation, to compositions containing them and to their use.
More particularly, the present invention relates to the use of purine derivatives in the treatment of a variety of viral infections and
1. FIELD OF THE INVENTION
The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological
FIELD OF THE INVENTION
The invention relates to purine and imidazopyridine derivatives useful as immunosuppressants.
BACKGROUND OF THE INVENTION
Immunosuppression is an important clinical approach in treating autoimmune disease and in preventing organ and tissue rejection. The clinically available
This application is the US national phase under 35 U.S.C. .sctn. 371 of international application PCT/EP2014/076843, filed Dec. 8, 2014, which claims priority to GB application 1321737.7, filed Dec. 9, 2013.
The present invention relates to a class of fused imidazole derivatives, and to their use in
FIELD OF THE INVENTION
This invention relates to novel substituted 6-(2-hydroxybenzylamino)purine derivatives, to their activity as polyspecific inhibitors of cyclin-dependent kinases 2, 5, 7, and 9 and to their use as medicaments.
BACKGROUND ART
The cyclin-dependent kinases (CDKs) are heterodimeric
TECHNICAL FIELD
The invention relates to 6,9-disubstituted purine derivatives as well as their use as, or in, cosmetics and/or cosmetic preparations.
BACKGROUND ART
In recent years, 6-substituted aminopurines have assumed considerable biochemical significance. Some compounds of this type promote
FIELD OF THE INVENTION
The invention relates to 8-substituted 2-(benzimidazolyl)purine derivatives and 8-substituted 2-(imidazolo[4,5-c]pyridinyl)purine derivatives useful as immunosuppressants.
BACKGROUND OF THE INVENTION
Immunosuppression is an important clinical approach in treating autoimmune