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ribonuclease/krabbamein
Krækjan er vistuð á klemmuspjaldið
Bls 1 frá 17 niðurstöður
Engineered cytotoxic ribonuclease A
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BACKGROUND OF THE INVENTION
The development of new drugs has contributed to the progress that has been made in recent years in the treatment of various types of cancer. However, certain cancers are refractory to the chemotherapeutic agents that are currently in use. These malignancies tend to be
Modified ribonucleases
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FIELD OF THE INVENTION
The present invention relates generally to conjugates of ribonucleases (e.g., human ribonucleases) and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of ribonucleases (e.g.,
Double-stranded nucleic acid, use and kit thereof in ribonuclease detection
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is an U.S. national stage of PCT/CN2012/081166, filed on Sep. 10, 2012, which claims priority to Chinese Patent Application No. 201110280177.8, filed on Sep. 20, 2011 and Chinese Patent Application No. 201110280179.7, filed on Sep. 20, 2011,
Compositions and methods for ribonuclease-based therapeutics
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FIELD OF THE INVENTION
The present invention relates generally to conjugates of ribonucleases (e.g., RNase 1 and RNase A) and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of ribonucleases and
Method of controlling lung tumor cell metastasis
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FIELD OF THE INVENTION
The present invention relates to an antitumor or antineoplastic agent and a tumor cell metastasis suppressive agent (hereinafter "antimetastatic agent"). Stated more specifically, it relates to an antitumor agent having a ribonuclease inhibitor as an active component, and more
Non-natural ribonuclease conjugates as cytotoxic agents
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FIELD OF THE INVENTION
The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been modified to make it toxic to target cells and that can be conjugated to a target
Non-natural ribonuclease conjugates as cytotoxic agents
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Skráðu þig / skráðu þig
FIELD OF THE INVENTION
The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been modified to make it toxic to target cells and that can be conjugated to a target
Non-natural ribonuclease conjugates as cytotoxic agents
Aðeins skráðir notendur geta þýtt greinar
Skráðu þig / skráðu þig
FIELD OF THE INVENTION
The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been modified to make it toxic to target cells and that can be conjugated to a target
Methods and compositions for the treatment of cancer
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FIELD OF THE INVENTION
The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent that is toxic to cells.
BACKGROUND OF THE INVENTION
The term "chemotherapy"
Recombinant anti-tumor RNAse
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FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT
Not applicable.
BACKGROUND OF THE INVENTION
Ribonucleases such as ribonuclease A ("RNase A") and their cytotoxicity towards tumor cells were discovered in the 1960s (reviewed in Roth, J., Cancer Res. 23:657 666 (1963)). In the 1970s, human serum was also
Bioparyl, a biological regulator, active against various pathologies
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BACKGROUND OF INVENTION
For the maintenance, and also for the division of cells, it is necessary for the cell to reproduce its genome (DNA), then to transcribe the genes (DNA) into various RNAs among which are messenger RNAs, which in turn direct the synthesis of proteins. The biological medium that
Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
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BACKGROUND OF THE INVENTION
Toxic enzymes from plants and bacteria such as ricin, diphtheria toxin and Pseudomonas toxin have been coupled to antibodies or receptor binding ligands to generate cell-type-specific-killing reagents (Youle, et al., Proc. Nat'l Acad. Sci. USA 77:5483 (1980); Gilliland,
Methods, compositions, and kits for collecting and detecting oligonucleotides
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CROSS-REFERENCE TO RELATED APPLICATIONS
The present application is related to U.S. patent application Ser. No. 12/157,985, entitled METHODS FOR COLLECTING AND DETECTING OLIGONUCLEOTIDES, naming Paul G. Allen, Edward S. Boyden, Roderick A. Hyde, Muriel Y. Ishikawa, Stephen L. Malaska, Dennis J.
Methods for collecting and detecting oligonucleotides
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SUMMARY
The method described herein comprises accurately sampling a RNA from a tissue of an animal and analyzing RNA in the tissue of the animal as an indicator of physiological state, infectious disease, neoplastic disease, autoimmune disease, inflammatory disease, cardiovascular disease, or
Methods for collecting and detecting oligonucleotides
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CROSS-REFERENCE TO RELATED APPLICATIONS
The present application is related to U.S. patent application Ser. No. 12/157,984, entitled METHODS, COMPOSITIONS, AND KITS FOR COLLECTING AND DETECTING OLIGONUCLEOTIDES, naming Paul G. Allen, Edward S. Boyden, Roderick A. Hyde, Muriel Y. Ishikawa, Stephen L.
Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum
- Virkar á 55 tungumálum
- Jurtalækningar studdir af vísindum
- Jurtaviðurkenning eftir ímynd
- Gagnvirkt GPS kort - merktu jurtir á staðsetningu (kemur fljótlega)
- Lestu vísindarit sem tengjast leit þinni
- Leitaðu að lækningajurtum eftir áhrifum þeirra
- Skipuleggðu áhugamál þitt og vertu vakandi með fréttarannsóknum, klínískum rannsóknum og einkaleyfum
Sláðu inn einkenni eða sjúkdóm og lestu um jurtir sem gætu hjálpað, sláðu jurt og sjáðu sjúkdóma og einkenni sem hún er notuð við.
* Allar upplýsingar eru byggðar á birtum vísindarannsóknum
