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[Antimutagenic properties of sea buckthorn oil].

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The influence of sea-buckthorn oil on cyclophosphamide, farmorubicin and dioxadet mutagenicity was studied. The oil decreased significantly the cytogenetic action of cyclophosphamide and farmorubicin, but not of dioxadet action. Possible mechanisms of antimutagenic action of the oil are discussed.

From the sea to anticancer therapy.

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Discovery, isolation, characterisation and pre-clinical and clinical trials of plant- or animal-derived drugs displaying pharmacological activities continue to develop and enlarge. Cancer chemotherapy is one of the most promising areas for these drugs. Since a very long time, nature has been an

Antitumor and antimicrobial glycoproteins from sea hares.

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1. Novel antitumor and antimicrobial glycoproteins were found in the sea hares. These glycoproteins were purified to apparent homogeneity from Aplysia kurodai, Aplysia juliana and Dolabella auricularia, and designated as aplysianins, julianins and dolabellanins, respectively. 2. The nine isolated

Anticancer activity of sea cucumber triterpene glycosides.

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Triterpene glycosides are characteristic secondary metabolites of sea cucumbers (Holothurioidea, Echinodermata). They have hemolytic, cytotoxic, antifungal, and other biological activities caused by membranotropic action. These natural products suppress the proliferation of various human tumor cell

Trabectedin: an anticancer drug from the sea.

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BACKGROUND Trabectedin (ET-743) is an anticancer agent originally isolated from Ecteinascidia turbinata, a marine organism. OBJECTIVE The goal of this review is to describe the chemical characteristics, mechanism of action and the results of clinical trials with this compound. The toxicities are

Antineoplastic substances from the sea: a review.

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Antineoplastic agents XLV: sea cucumber cytotoxic saponins.

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Sea-originated cytotoxic substances.

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Cancer accounted for huge number of deaths, which represents about 13% of all deaths worldwide, and the number of the deaths due to cancer is increasing. Natural products and their synthetic analogs are widely used as antitumor drugs. As represented by these drugs, many anticancer drugs originated

Sea Cucumbers Metabolites as Potent Anti-Cancer Agents.

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Sea cucumbers and their extracts have gained immense popularity and interest among researchers and nutritionists due to their nutritive value, potential health benefits, and use in the treatment of chronic inflammatory diseases. Many areas of the world use sea cucumbers in traditional foods and folk

Antineoplastic agents. 76. The sea urchin Strongylocentrotus droebachiensis.

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An improved procedure based on centrifugation at 37,000 g has been developed for isolating the antineoplastic glycoprotein strongylostatin 1 from Strongylocentrotus droebachiensis (Müller). The green sea urchin has also been found to contain a second protein anticancer constituent designated

Synthesis of Sea Cucumber Saponins with Antitumor Activities

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Holostane glycosides are characteristic metabolites of sea cucumbers, which possess various biological activities. Here we report the synthesis of two representative congeners, namely pervicoside B and C, starting from lanosterol with the longest linear sequence of both 34 steps and in 0.3% overall

Bioactive molecules from sea hares.

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Sea hares, belonging to the order Opisthobranchia, subclass Gastropoda, are mollusks that have attracted many researchers who are interested in the chemical defense mechanisms of these soft and "shell-less" snails. Numbers of small molecules of dietary origin have been isolated from sea hares and

Researchers optimistic about sea change in cancer treatment.

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The origin of antitumour activity in sea anemones.

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Pharmacological Potential of Sea Cucumbers.

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This review presents a detailed analysis of published research data focused on the pharmacological activity exerted by biologically active compounds isolated from sea cucumbers belonging to the class of Holothuroidea, phylum Echinodermata. The review contains descriptions of the structure,

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