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Short-term Clinical Study of CN128 in Thalassemia Patients

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1. Primary objectives: - To study the tolerance and safety of multiple oral administration of CN128 in patients with thalassemia aged 16 years and above. - To study the pharmacokinetics of CN128 in thalassemia patients aged 16 and above by multiple oral administrations of CN128 2. Design: The study

Breast Cancer and Its Relationship With the Microbiota

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The study will follow the Declaration of Helsinki and the Spaniard legislation regarding clinical research. Data obtained will be confidential and only the researchers and participants, upon request, will have access to them. The study will also follow the data protection legislation of Spain to

Occupational Health Hazards Among Flour Mills Workers

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Flour is a complex organic dust consisting of one or a mixture of several cereal grains (wheat, rye, millet, barley, oats or corn cereal) that have been processed or ground by milling. In addition, flour may contain a diverse number of contaminants, such as silica, fungi and their metabolites

Clinical Study of CN128 in Thalassemia Patients

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1. Primary objectives: · To determine the maximum tolerated dose (MTD) of CN128 for single oral administration in thalassemia patients aged 16 and above · To study the pharmacokinetics of CN128 in thalassemia patients aged 16 and above 2. Design: The study is designed as a randomized, double-blind,

A First in Human Study Using 89Zr-cRGDY Ultrasmall Silica Particle Tracers for Malignant Brain Tumors

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Structural Network on Prostate Cancer in the French Greater West Region

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Relevance and strategic approach Prostate Cancer (PCa) is the most common cancer in men and the second leading cause of cancer deaths in western countries. Known risk factors are advanced age, ethnic origins and positive family history of the disease (1). There are considerable ethnic disparities in

Circulating Tumour DNA (ctDNA) Rectal Cancer and the Relationship to Extramural Venous Invasion

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Vascular or venous invasion in patients with rectal cancer has been considered a significant prognostic factor for over half a century. Interest in understanding the mechanisms that govern tumour spread from the rectum to distant sites such as the liver has driven the study of lymphatic and vascular

Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies

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BACKGROUND Pulmonary hypertension is a severe disorder defined by an elevated mean pulmonary arterial pressure (mPAP) as >25 mmHg at rest. A classification of the different types of pulmonary hypertension has been established according to shared pathologic and clinical features as well as similar

Clinical Cohorts in Coronary Disease Collaboration

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Obtaining participant consent Patients were invited to read a study information sheet and encouraged to ask questions about the research, after which written informed consent was sought from patients for: a) completion of a baseline health questionnaire; b) provision of a blood sample for long-term

Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures 2

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Study rationale: The main risk factors of COPD are tobacco smoking, biomass smoking and occupational factors. Tobacco smoking is well-known risk factor so tobacco induced COPD is completely established. Nevertheless the meaning of occupational factors which are less famous are equally important.

Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures

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Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery

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Simethicone is an orally administered anti-foaming agent comprised of polydimethylsiloxane and hydrated silica gel. Its leads to the coalescence of gas bubbles in the intestinal tract, facilitating its emission. To date, there are no contemporary studies evaluating the efficacy of simethicone on POI

Targeted Silica Nanoparticles for Real-Time Image-Guided Intraoperative Mapping of Nodal Metastases

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Short-term High Precision Radiotherapy for Early Prostate Cancer With Concomitant Boost on the Dominant Lesion

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Approximately 70% of men with newly diagnosed prostate cancer feature organ-confined disease. Conventional treatment options for prostate-confined cancer include radical prostatectomy, external beam radiation therapy, brachytherapy and active surveillance. All currently available treatments have

Plasmonic Nanophotothermal Therapy of Atherosclerosis

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Cardiovascular disease (CVD) is one of the main cause of disability and death worldwide. The underlying cause generally is atherosclerosis and more in particular thrombotic rupture of an atherosclerotic plaque in a vital artery. The restoration of blood flow to ischemic myocardium is established as

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Herbal & Natural Medicine

Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum

Virkar á 55 tungumálum
Jurtalækningar studdir af vísindum
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