testicular neoplasms/hypoxia

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Successful management of a patient with radiological presentation of choriocarcinoma syndrome before induction chemotherapy.

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Choriocarcinoma syndrome is a life-threatening lysis syndrome caused by blood vessel rupture and subsequent tumor bleeding. We describe a case of pretreatment choriocarcinoma syndrome that developed in a 27-year-old man. He underwent a high orchiectomy at a local hospital and was diagnosed with

Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors.

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Testicular germ cell tumors (TGCTs) represent a highly curable malignancy, however a small proportion of patients fails to be cured with cisplatin-based chemotherapy. Carbonic anhydrase IX (CA IX) is upregulated by hypoxia in several cancer types and correlates with a poor prognosis. The present

Treatment of spontaneous tumours by temporary local ligation. A comparative study in dogs.

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Previous work in some human cases and in laboratory animals has indicated that temporary local ligation of spontaneous tumours has a selective destructive effect on these tumours, with only temporary inflammation resulting in normal tissues. In the experiments described in this paper, 49 spontaneous

Large-dose bleomycin therapy and pulmonary toxicity. A possible role of prior radiotherapy.

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Bleomycin sulfate pulmonary toxicity was encountered in nine of 101 patients receiving high-dose therapy for widespread testicular cancer. The pulmonary presentation was separable into two categories: (1) an early or minimal from with dyspnea on exertion, minimal roentgenographic findings, and

An unusual case of high altitude-like retinopathy caused by anemia and thrombocytopenia at recreational altitude.

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OBJECTIVE To report an unusual presentation of high altitude-like retinopathy at recreational altitude after chemotherapy-induced anemia and thrombocytopenia. METHODS Case report. RESULTS A 43-year-old man undergoing chemotherapy for testicular cancer traveled to an altitude of 2,930 m and

Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4, c-Myc, Sox2 and Klf4.

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The male germinal lineage, which is defined as unipotent, produces sperm through spermatogenesis. However, embryonic primordial germ cells and postnatal spermatogonial stem cells (SSCs) can change their fate and convert to pluripotency in culture when they are not controlled by the testicular

Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells.

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Signaling by the receptor for stem cell factor (SCF), c-Kit, is of major importance for hematopoiesis, melanogenesis and reproduction, and the biological responses are commonly proliferation and cell survival. Thus, constitutive activation due to c-Kit mutations is involved in the pathogenesis of

Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations.

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BACKGROUND Leydig cell tumors (LCTs) are the most common non-germ-cell neoplasms of the testis. LCTs are often hormonally active and can result in precocious virilization or in adult feminization. We identified an LCT in an affected individual from a kindred with hereditary leiomyomatosis and renal

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