8 oz. Concord grape juice + 450 mg Grape seed polyphenol extract + 150 mg Trans-resveratrol

16 oz. Concord grape juice + 900 mg Grape seed polyphenol extract + 300 mg Trans-resveratrol

24 oz. Concord grape juice + 1200mg Grape seed polyphenol extract + 450mg Trans-resveratrol

Healthy Control

Trans-resveratrol

Concord grape juice

Grape seed polyphenol extract

Comparable placebo supplement which is manufactured according to GMP and will contain inert substances.

Placebo

Icahn School of Medicine at Mount Sinai

Metabolism of Bioactive Dietary Polyphenol Preparation (BDPP)

Clinical Pharmacology and Target Validation of A Bioactive Dietary Polyphenol Preparation (BDPP) For Stress-Related Disorders

Bioavailability assessed to show a dose-dependent increase in key BDPP metabolites, including DHCA.

James Murrough

Associate Professor

This is a single center, double-blind, placebo-controlled, randomized phase I trial. Each subject will be randomized to a daily low, medium or high dose of BDPP or placebo.

Participants and investigators will be masked to whether they are assigned to study supplement or placebo.

Participants with receive resveratrol at 150 mg daily for 6 weeks

Chemoprevention

Participants will receive Resveratrol at 150 mg daily for 6 weeks.

Resveratrol (RSV)

Loma Linda University Cancer Center

Effect of Resveratrol on Serum IGF2 Among African American Women

Mechanisms in IGF2 Induced Chemoresistance and Mitochondrial Regulation in Triple Negative Breast Cancer

To determine changes in the levels of IGF-II (mIGF2 or Pro-IGF2)

To determine changes in the levels of IGFBP-3 levels

Gayathri Nagaraj

Principle Investigator

Loma Linda University

Participants take 500 mg of PolyResveratrol (100 mg curcumin phytosome, 100 mg quercetin phytosome, 100 mg green tea phytosome, 100 mg trans-resveratrol, 100 mg trans-pterostilbene; Thorne Research) twice daily for one week. Two blood Draws are taken on both the first and last days of the week. One blood draw is done fasted just before consumption of one supplement dose, and one blood draw is done after consumption of one supplement dose.

Participants take 500 mg of Curcumin phytosome twice daily for one week. Two blood draws are taken on both the first and last days of the week. One blood draw is done fasted just before consumption of one supplement dose, and one blood draw is done after consumption of one supplement dose.

Inflammation

Atherosclerosis

Cardiovascular Disease

Participants will take 1 mg of a polyresveratrol phytosome supplement each day for one week. The acute effect (1 hr) of one 500 mg dose of the polyresveratrol phytosome supplement on inflammation will be examined along with the short-term effect (1 week).

PolyResveratrol Supplementation

Participants will take 1 mg of a curcumin phytosome supplement each day for one week. The acute effect (1 hr) of one 500 mg dose of the curcumin phytosome supplement on inflammation will be examined along with the short-term effect (1 week).

Curcumin Supplementation

Clinical Exercise Research Center

Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL

VCAM-1 and ICAM-1 expression in whole plasma will be measured at baseline, and one hour after a single dose of each supplement using flow cytometry. Differences in one-hour changes in inflammation between each supplement will be compared.

VCAM-1 and ICAM-1 expression in whole plasma will be measured at baseline, and after one week of supplementation for each supplement using flow cytometry. Differences in one-week changes in inflammation between each supplement will be compared.

VCAM-1 and ICAM-1 expression in HDL plasma will be measured at baseline, and one hour after a single dose of each supplement using flow cytometry. Differences in one-hour changes in inflammation between each supplement will be compared.

VCAM-1 and ICAM-1 expression in HDL plasma will be measured at baseline, and after one week of supplementation for each supplement using flow cytometry. Differences in one-week changes in inflammation between each supplement will be compared.

HDL cholesterol efflux capacity will be measured at baseline, one hour after a single dose, and after a week of supplementation in non-apolipoprotein B containing plasma.

University of South Carolina

Polycystic Ovary Syndrome (PCOS)

Micronized trans-resveratrol

Poznan University of Medical Sciences

Effects of Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients

Effects of Micronized Trans-resveratrol Treatment on Clinical, Endocrine, Metabolic and Biochemical Parameters of Women With Polycystic Ovary Syndrome: Placebo-controlled Randomized Single-blind Study

Beata Banaszewska

MD PhD

University of California, Davis

Sports Concussion

The dose of resveratrol is 500 mg. The route of administration is oral, once-a-day for 30 days after injury.

Resveratrol

The placebo is a sugar pill. The route of administration is oral, once-a-day for 30 days after injury.

University of Texas Southwestern Medical Center

Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Related Concussions in Boxers

Use of Resveratrol to Decrease Secondary Brain Injury Following Sports-Related Concussions: a Double-Blind, Placebo-Controlled Study

To determine safety, Liver Function Tests will be conducted at day 7 and 30 in the boxers after experiencing a concussion to screen for asymptomatic adverse events.

The ImPACT cognitive test performance of each subject will be compared to their baseline scores. We hypothesize that resveratrol will improve cognitive performance after injury.

We will determine the efficacy of resveratrol on decreasing axonal injury in the brain using magnetic resonance imaging (MRI) at day 7 after injury.

trans resveratrol/bólga

Metabolism of Bioactive Dietary Polyphenol Preparation (BDPP)

Effect of Resveratrol on Serum IGF2 Among African American Women

Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL

Effects of Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients

Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Related Concussions in Boxers

Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum