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Particle-water interactions of platinum-based anticancer drugs in river water and estuarine water.

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The cytotoxic, platinum-based anticancer drugs, cisplatin, carboplatin and oxaliplatin, enter the aquatic environment largely in municipal wastes via excretion from outpatients undergoing chemotherapy. The environmental behaviour, effects and fate of these drugs are, however, unknown. In this study,

[Antitumor effect of a water-in-oil-in-water type adriamycin emulsion on Ehrlich solid tumor-bearing mice].

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Antitumor effect of water-in-oil-in-water type adriamycin emulsion (emulsion ADM) was examined in comparison with free ADM on the survival time of ICR male mice bearing Ehrlich solid tumor after a subcutaneous inoculation and on the tumor growth by the subcutaneous (SC-SC) or intraperitoneal

Platinum-based anticancer drugs in waste waters of a major UK hospital and predicted concentrations in recipient surface waters.

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Concentrations of the cytotoxic platinum-based anticancer drugs, as total Pt, have been measured over a three week period in one of the main drains and in the effluent of the oncology ward of a major UK hospital (Derriford, Plymouth). Concentrations of Pt were highly variable in both discharges, and

Synthesis and antitumor activities of water-soluble benzoylphenylureas.

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Water-soluble benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. Some of the prodrugs were highly soluble in water and showed good antitumor activities against P388 leukemia cells in mice when injected

Preclinical antitumor activity of water-soluble paclitaxel derivatives.

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OBJECTIVE Five water-soluble paclitaxel derivatives were extensively evaluated for their antitumor activities relative to the parent drug. METHODS Both subcutaneous (s.c.) murine (M109 lung) and human (A2780 ovarian, L2987 lung) tumor models were used for this purpose. RESULTS Consecutive daily

Using water-soluble C60 fullerenes in anticancer therapy.

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Growth experiments of transplanted malignant tumors in the presence of water-soluble C60 fullerenes were performed on groups of mice. It was found that C60 fullerenes efficiently inhibit the growth of transplanted malignant tumors. This behavior can be explained through their high antioxidant

Antimutagenic properties of fresh-water blue-green algae.

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The antimutagenic properties of whole fresh-water blue-green algae Aphanisomenon flos-aquae, marketed under the commercial name "Alpha Sun" were tested using the Ames test. Simultaneous addition of both algae and Nitrovin (a mutagen) to the test medium did not reduce the mutagenic activity. On the

A water-soluble antitumor glycoprotein from Chlorella vulgaris.

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An active substance with antitumor activity (ARS2) was purified from the culture media of Chlorella vulgaris and found to be a glycoprotein with a molecular weight of 63,100 amu, as determined by matrix-assisted laser desorption/ ionization (MALDI) mass spectrometry. ARS2 contains 66.9%

Water-soluble platinum phthalocyanines as potential antitumor agents.

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Breast cancer represents the second cause of death in the European female population. The lack of specific therapies together with its high invasive potential are the major problems associated to such a tumor. In the last three decades platinum-based drugs have been considered essential constituents

N-succinyl-chitosan as a drug carrier: water-insoluble and water-soluble conjugates.

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N-succinyl-chitosan (Suc-Chi) has favourable properties as a drug carrier such as biocompatibility, low toxicity and long-term retention in the body. It was long retained in the systemic circulation after intravenous administration, and the plasma half-lives of Suc-Chi (MW: 3.4 x 10(5);

Poorly water-soluble drug nanoparticles via solvent evaporation in water-soluble porous polymers.

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A generic method is described to form poorly water-soluble drug nanoparticles within water-soluble porous polymer by solvent evaporation. The simple dissolution of porous polymer with drug nanoparticles results in stable aqueous drug nanoparticle suspension under the optimized conditions. The porous

Synthesis and anticancer properties of water-soluble zinc ionophores.

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Several water-solubilized versions of the zinc ionophore 1-hydroxypyridine-2-thione (ZnHPT), synthesized as part of the present study, have been found both to increase the intracellular concentrations of free zinc and to produce an antiproliferative activity in exponential phase A549 human lung

Antitumor activity of hot-water extract from delipidated BCG.

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The antitumor activity of hot-water extract of delipidated BCG was investigated in mice inoculated with Sarcoma-180 cells and Ehrlich carcinoma cells, respectively. The hot-water extract was found to be effective when administered after and ineffective when administered before the inoculation of

Spartium junceum aromatic water: chemical composition and antitumor activity.

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The purpose of this study was to analyse the chemical composition of Spartium junceum L. (also known as Spanish Broom) aromatic water and to evaluate its cytotoxic activity against a series of human cancer cell lines (melanoma: RPMI 7932; leukemia: K562; breast cancer cell: MCF7-Bart and MCF7-ICLC,

In vivo antitumor activity of novel water-soluble taxoids.

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The antitumor activity of newly developed taxoids possessing a sugar moiety (glucose, galactose or mannose) to improve water solubility was evaluated. Galactose-bound taxoid (10-alpha-GAG-DT) proved superior to all other taxoids in both water solubility and antitumor activity. Therapeutic efficacy

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