Bioorganic and Medicinal Chemistry Letters 2001-May
Adamantylaminopyrimidines and -pyridines are potent inducers of tumor necrosis factor-alpha.
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A series of (1-adamantyl)aminopyrimidine and -pyridine derivatives was prepared by adamantyl cation attack on amino heterocycles. The adamantylated compounds, particularly 2-(1-adamantyl)amino-6-methylpyridine, were found to be potent TNF-alpha inducers in murine melanoma cells transduced with gene for human TNF-alpha.