Alimentary Pharmacology and Therapeutics 1987-Jun
Adverse reactions to sulphasalazine and 5-amino salicylic acid in the same patient.
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We report a patient who developed sulphasalazine-related hepatitis with a subsequent adverse reaction to rectal 5-amino salicylic acid, in the form of pain and fever without associated liver dysfunction, suggesting reactions to both components of sulphasalazine. Included is a review of the literature. Caution should be observed when prescribing 5-amino salicylic acid to sulphasalazine-intolerant patients.