Open Access Macedonian Journal of Medical Sciences 2019-Aug
Blood Cortisol Level and Blood Serotonin Level in Depression Mice with Basil Leaf Essential Oil Treatment.
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BACKGROUND
Depression is a serious public health problem. The impact of depression is enormous, ranging from decreasing work productivity, interpersonal disorders, sleep and eating disorders, susceptible to disease to an increase in suicides. In a state of depression, there was an increase in cortisol and changes in the neurotransmitter of the brain monoamine, norepinephrine and dopamine and specifically serotonin level. Treatment of depression using synthetic drugs such as the Selective Serotonin Reuptake Inhibitor (SSRI) drug which is said to be safe turns out to still have side effects, such as stomach disorders, erectile disorders, weight gain and sometimes sleep disorders. So, the usage of traditional medicines can be an alternative. One of the traditional medicines that have been studied in Indonesia was the essential oil of basil leaves, which is known to function as an antidepressant at a dose of 2.5 x 10-2 mL/kg b.w.METHODS
This research was an experimental type purely using experimental animal models, with an experimental research design Post Test Only Context Group Design in mice (Mus musculus), by dividing 3 groups of mice, namely depressed mice which received essential oil of basil leaves dose of 2.5 x 10-2 mL/kg BW, depression mice, and normal mice, to compare the level of blood cortisol and serotonin while to determine effect of administration basil leaves essential oils in depression mice.