Italian
Albanian
Arabic
Armenian
Azerbaijani
Belarusian
Bengali
Bosnian
Catalan
Czech
Danish
Deutsch
Dutch
English
Estonian
Finnish
Français
Greek
Haitian Creole
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Irish
Italian
Japanese
Korean
Latvian
Lithuanian
Macedonian
Mongolian
Norwegian
Persian
Polish
Portuguese
Romanian
Russian
Serbian
Slovak
Slovenian
Spanish
Swahili
Swedish
Turkish
Ukrainian
Vietnamese
Български
中文(简体)
中文(繁體)
Journal of Cardiology 2019-Nov

Different effects of norepinephrine and nerve growth factor on atrial fibrillation vulnerability.

Solo gli utenti registrati possono tradurre articoli
Entra registrati
Il collegamento viene salvato negli appunti
Mei Yang
Shudi Zhang
Jinjun Liang
Yanhong Tang
Xi Wang
Congxin Huang
Qingyan Zhao

Parole chiave

Astratto

The sympathetic nerve plays an important role in atrial fibrillation (AF) vulnerability. Norepinephrine (NE) has a relationship with AF and nerve growth factor (NGF) injection can induce sympathetic innervation. However, the mechanisms of NE and NGF on AF vulnerability remain unclear.Four groups of rabbits were studied: the control group, the NGF group, the NE group, and the NGF+valsartan+metoprolol group. After receiving drugs for 15 days, induced AF was observed, and left atrium (LA) tissues were obtained. Immunocytochemical staining of cardiac nerves and ionic remodeling were performed using anti-growth-associated protein 43 (GAP43), anti-tyrosine hydroxylase (TH) antibodies, and patch clamp.

RESULTS
The incidence of AF was significantly higher (p<0.01) in the NGF group and the NE group than in the control group and the NGF+valsartan+metoprolol group. The nerve densities for TH and GAP43-positive at the LA were significantly higher (p<0.01) after NGF, but the nerve densities decreased after NE. ICa,L was increased while instant outward K+ channel current (Ito) was decreased in the LA of rabbits after treatment with NGF and NE. Metoprolol and valsartan can reverse the ICa,L and Ito remodeling and the vulnerability to AF. However, these drugs did not inhibit the effect of NGF on sympathetic sprouting.

The effects of NE and NGF on AF vulnerability have a relationship with the ionic remodeling, while the sympathetic hyperinnervation did not have a strong association with the induction of AF.

Unisciti alla nostra
pagina facebook

Il database di erbe medicinali più completo supportato dalla scienza

  • Funziona in 55 lingue
  • Cure a base di erbe sostenute dalla scienza
  • Riconoscimento delle erbe per immagine
  • Mappa GPS interattiva - tagga le erbe sul luogo (disponibile a breve)
  • Leggi le pubblicazioni scientifiche relative alla tua ricerca
  • Cerca le erbe medicinali in base ai loro effetti
  • Organizza i tuoi interessi e tieniti aggiornato sulle notizie di ricerca, sperimentazioni cliniche e brevetti

Digita un sintomo o una malattia e leggi le erbe che potrebbero aiutare, digita un'erba e osserva le malattie ei sintomi contro cui è usata.
* Tutte le informazioni si basano su ricerche scientifiche pubblicate

Google Play badgeApp Store badge