Early Hyperoxia in the Intensive Care Unit is Significantly Associated with Unfavorable Neurological Outcomes in Patients with Mild-to-Moderate Aneurysmal Subarachnoid Hemorrhage.
Parole chiave
Astratto
BACKGROUND
Although oxygen administration is fundamental in the management of aneurysmal subarachnoid hemorrhage (SAH) patients in the acute stage, hyperoxia has harmful effects. The effects of hyperoxia on neurological outcomes in SAH patients are unclear. We aimed to examine the association of hyperoxia during the first 24 h in the intensive care unit (ICU) with unfavorable neurological outcomes in SAH patients.
METHODS
We retrospectively selected consecutive adult patients admitted to ICU for SAH between January 2009 and April 2018. We defined normoxia during the first 24 h in ICU as PaO2 of 60-120 mmHg, mild hyperoxia as PaO2 of 121-200 mmHg, moderate hyperoxia as PaO2 of 201-300 mmHg, and severe hyperoxia as PaO2 of >300 mmHg. Univariate and multivariate analyses were performed to examine the association between hyperoxia during the first 24 h in ICU and unfavorable neurological outcomes (i.e., modified Rankin scale score of 3-6 at hospital discharge).
RESULTS
Among 196 SAH patients, 90 had unfavorable neurological outcomes. Hyperoxia was observed in 93.4% of patients. No significant association was observed between unfavorable neurological outcomes and hyperoxia in overall patients. However, we found that early hyperoxia in ICU was significantly associated with unfavorable neurological outcomes in SAH patients with Hunt and Kosnik (H&K) grades I-III (Relative risk, 1.84; 95% confidence interval, 1.10-2.94; p = 0.02).
CONCLUSIONS
Early hyperoxia was not associated with unfavorable neurological outcomes in overall SAH patients, but it was associated with unfavorable neurological outcomes in those with H&K grades I-III.
