Eksperimental'naya i Klinicheskaya Farmakologiya
[Immunomodulating effect of the novel water-soluble gossypol derivative Mebavin in adjuvant arthritis].
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Investigation of the effect of mebavin on the model of adjuvant arthritis showed that this drug administered in a dose of 100 mg/kg exhibits immunomodulant and anti-inflammatory activity without negative influence on the nonspecific response of the organism. Combined administration of mebavin with prednisolone provides for a more effective and nontoxic treatment of adjuvant arthritis.