Journal of Cancer Research and Therapeutics 2018-Dec
Influence of pharmorubicin on the left ventricular ejection fraction of patients with breast cancer: A mechanism study.
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Materials and Methods
Patients with breast cancer were enrolled at the same hospital. Group I consisted of 135 samples, who were under treatment of pharmorubicin (200 mg/m2). Group II consisted of 144 samples, who were under treatment the of pharmorubicin (360 mg/m2). Group III was used as control group, which consists of 120 samples without treatment of pharmorubicin. Color Doppler ultrasonic inspection and measurement were performed to examine EF. Flow cytometry was performed to assess oxygen free radical level in hemocytes. Further combination therapy (N-acetylcysteine [NAC] + pharmorubicin) was provided for patients, and the same examinations were performed for the assessment of cardiac function and oxygen free radical level.