Clinica Chimica Acta 1978-Dec
Study of influence of sex and age on human serum lysosomal enzymes by using 4-methylumbelliferyl substrates.
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The sex and age dependence of activity of eight glycosidases and acid phosphatase was assayed in serum samples using the 4-methylumbelliferyl substrates. The activity of these enzymes does not change in relation to sex and to age except for acid phosphatase and beta-galactosidase which show significantly higher values in children as compared to adults. The usefulness of the 4-MU substrates for the detection of homozygotes for those lysosomal diseases involving one of the glycosidases studied is discussed.