Ocular Immunology and Inflammation 2014-Jun
Systemic side effects of antiviral therapy in a patient with acute retinal necrosis.
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OBJECTIVE
To report a case of Acute Retinal Necrosis (ARN)-developed nephrotoxicity during intravenous acyclovir treatment and toxic hepatitis during oral valacyclovir treatment.
METHODS
Interventional case report.
METHODS
Retrospective chart review.
RESULTS
A 45-year-old male with ARN treated with intravenous acyclovir developed nephrotoxicity. After switching to oral valacyclovir, toxic hepatitis developed. Both renal and liver function tests returned to normal levels after drug cessation
CONCLUSIONS
Although rare, clinicians should be aware of the potential nephrotoxic and hepatotoxic side effects of antiviral therapy during ARN treatment.
