Weight loss surgery improves quality of life in pediatric patients with osteogenesis imperfecta.
Parole chiave
Astratto
BACKGROUND
Osteogenesis imperfecta (OI) is an inherited disorder, which causes brittle bones resulting in recurrent fractures. The associated poor mobility of children with OI increases susceptibility to obesity, and obesity further dramatically limits mobility and increases fracture risk.
OBJECTIVE
The aim of this report is to describe outcomes of weight loss surgery (WLS) in 2 adolescents with severe obesity and OI.
METHODS
Two University Hospitals (in the United Kingdom and in the United States).
METHODS
Two cases of OI treated with WLS were identified. Pre- and postoperative anthropometric and biochemical data and clinical course were reviewed.
RESULTS
In these 2 cases, preoperative Body Mass Index (BMI) values were 38 and 46 kg/m2. Following laparoscopic sleeve gastrectomy (LSG), BMI decreased by 55% and 60% by 26 and 24 months, respectively. There were no surgical complications, and both patients experienced improvement in their mobility and ability to perform activities of daily living.
CONCLUSIONS
WLS effectively treated severe obesity in 2 OI patients and substantially improved mobility and quality of life, theoretically reducing fracture risk.
