acetylcysteine/vomito

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Ondansetron to prevent emesis following N-acetylcysteine for acetaminophen intoxication.

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We present a 17-year-old girl who developed persistent vomiting following acetaminophen overdose. Because of the amount of drug ingested (300 mg/kg acetaminophen) and the four-hour postingestion level (256 micrograms/ml), administration of N-acetylcysteine (NAC) was indicated. Emesis occurred

Effect of metoclopramide dose on preventing emesis after oral administration of N-acetylcysteine for acetaminophen overdose.

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OBJECTIVE To determine the effect of the metoclopramide dose on the prevention of vomiting of N-acetylcysteine in acetaminophen overdose. METHODS Patients with acetaminophen ingestions receiving metoclopramide prior to emergency department administration of N-acetylcysteine were included. Emergency

A randomised, double blind trial of N-Acetylcysteine for hearing protection during stapes surgery.

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BACKGROUND Otosclerosis is a disorder that impairs middle ear function, leading to conductive hearing loss. Surgical treatment results in large improvement of hearing at low sound frequencies, but high-frequency hearing often suffers. A likely reason for this is that inner ear sensory cells are

A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning.

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BACKGROUND Acetylcysteine prevents hepatic injury when administered soon after acetaminophen overdose. The most commonly used treatment protocols are a 72-hour oral and a 21-hour intravenous (IV) protocol. Between 1984 and 1994, 409 patients were enrolled in a study to describe the outcomes of

Use of N-acetylcysteine in children with fulminant hepatic failure caused by acute viral hepatitis.

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OBJECTIVE To determine the efficacy of N-acetylcysteine (NAC) in children aged > 1 month to 16 years admitted with Fulminant Hepatic Failure (FHF) secondary to Acute Viral Hepatitis (AVH) in a tertiary care center of a developing country. METHODS Analytical study. METHODS Department of Paediatrics,

The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoning.

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BACKGROUND Nausea and vomiting associated with poisoning can complicate treatment and in some cases delay potential antidote administration. Side effect such as lowering the seizure threshold may at times discourage the use of traditional phenothiazine and butyrophenone antiemetics. METHODS We

Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose.

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BACKGROUND Adverse effects to N-acetylcysteine (NAC) are well recognized, but their etiology and incidence are unclear. METHODS The nature and severity of adverse effects were prospectively studied in 169 patients and potential reaction mediators studied in 22 patients. RESULTS Adverse effects were

[Post-marketing surveillance of acetylcysteine oral solution 17.6% "SENJU" for the antidote to acetaminophen overdose--use--results surveillance].

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Use-result surveillance was conducted to investigate the safety and efficacy of Acetylcysteine Oral Solution 17.6 % "SENJU" having the indication for the antidote to acetaminophen (Paracetamol) overdose. Ninety six cases (patients) were collected for the safety evaluation, and 13 cases (incidence

A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent

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Introduction: Anaphylactoid reactions are well-documented adverse events associated with the intravenous administration of N-acetylcysteine (NAC) in patients with acetaminophen overdose. Most reactions are mild, occurring within the first

Successful use of N-acetylcysteine to treat severe hepatic injury caused by a dietary fitness supplement.

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In the absence of adequate premarketing efficacy and safety evaluations, adverse events from over-the-counter supplements are emerging as a public health concern. Specifically, bodybuilding products are being identified as a frequent cause of drug-induced liver injury. We present a case of a

Respiratory paradoxical adverse drug reactions associated with acetylcysteine and carbocysteine systemic use in paediatric patients: a national survey.

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OBJECTIVE To report pediatric cases of paradoxical respiratory adverse drug reactions (ADRs) after exposure to oral mucolytic drugs (carbocysteine, acetylcysteine) that led to the withdrawal of licenses for these drugs for infants in France and then Italy. METHODS The study followed the

[Acute liver failure caused by paracetamol: should treatment with N-acetylcysteine be prolonged?].

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BACKGROUND Some cases of paracetamol-induced acute hepatic failure may require liver transplantation but the present shortage of graft urges the search for an alternate therapeutic approach. METHODS A 17 year-old girl was admitted for sleepingness and vomiting after about 15 hours of voluntary but

N-acetylcysteine in severe falciparum malaria in Thailand.

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One hundred and eight patients with severe falciparum malaria underwent a placebo controlled trial with the antioxidant, N-acetylcysteine (NAC), as an adjunctive therapy along with standard intravenous artesunate therapy. Three NAC dosage regimens were used: an intravenous loading dose of 140 mg/kg

Early treatment with N-acetylcysteine in children with acute liver failure secondary to hepatitis A.

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BACKGROUND Hepatitis A virus can evolve to acute liver failure with a fatal outcome if it is not reversed. OBJECTIVE We describe the clinical course of 12 children who presented with hepatitis A acute liver failure and received treatment with oral N-acetylcysteine (NAC). METHODS Of the seventy-two

Possible role for acetylcysteine as a treatment for acute liver failure secondary to antitubercular medication use

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Purpose: Drug-induced liver injury (DILI) that progresses to acute liver failure (ALF) has a high mortality rate, and therapeutic options are limited. Acetylcysteine has a labeled indication for use as an antidote for acetaminophen

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