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3 risultati
Design of novel ROCK inhibitors using fragment-based de novo drug design approach
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Rho-associated coiled-coil protein kinase (ROCK) is playing a vital role in the regulation of key cellular events and also responsible for causing several pathological conditions such as cancer, hypertension, Alzheimer's, cerebral vasospasm, and cardiac stroke. Therefore, it has attracted us to
Achyranthes aspera Linn. alleviates cerebral ischemia-reperfusion-induced neurocognitive, biochemical, morphological and histological alterations in Wistar rats.
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BACKGROUND
In the traditional system of Indian medicine, the whole plant and roots of Achyranthes aspera L have been extensively used to treat neurological conditions such as epilepsy and stroke by the various ethnic communities of India.
OBJECTIVE
The present study was aimed to evaluate the
Chemical characterization and cerebroprotective effect of methanolic root extract of Colebrookea oppositifolia in rats.
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BACKGROUND
Colebrookea oppositifolia Smith is one of the extensively used plants to treat neurological conditions such as epilepsy by the various ethnic communities in sub-Himalayan regions of India such as Bhoxa, Tharu and nomadic Gujjars.
OBJECTIVE
This study was conducted to evaluate the
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